Effects of Chicory on Serum Uric Acid, Renal Function, and GLUT9 Expression in Hyperuricaemic Rats with Renal Injury and In Vitro Verification with Cells
Effects of Chicory on Serum Uric Acid, Renal Function, and GLUT9 Expression in Hyperuricaemic Rats with Renal Injury and In Vitro Verification with Cells
复制标题
菊苣对肾损伤高尿酸血症大鼠血清尿酸、肾功能和 GLUT9 表达的影响及细胞体外验证。
DOI：
10.1155/2018/1764212
复制
发表时间：
2018-01-01
影响因子：
--
通讯作者：
Bai, Yun-Fei
中科院分区：
文献类型：
--
作者：
Jin, Yong-Nan;Lin, Zhi-Jian;Bai, Yun-Fei
高尿酸血症（HUA）是慢性肾脏疾病的独立危险因素。尿酸盐晶体沉积在肾脏中，可引起肾小管间质纤维化，导致肾功能障碍。菊苣提取物（以下简称菊苣）明显降低10%果糖诱导HUA大鼠血清尿酸水平。本研究首次观察了菊苣对HUA和肾损伤大鼠血清尿酸水平和肾功能的影响。酵母和腺嘌呤诱导的高尿酸血症肾损伤大鼠的体内研究表明，菊苣降低血清尿酸水平，其延缓肾损伤进展的作用优于苯溴马隆。体外细胞实验表明，这种作用与抑制肾小管GLUT9蛋白表达有关，降低血尿酸浓度是减轻肾损害的因素之一。本研究结果提示菊苣可作为缓解高尿酸血症患者肾功能障碍的一种替代药物。
Hyperuricaemia (HUA) is an independent risk factor for chronic kidney disease. Urate crystals are deposited in the kidney and can cause renal tubular interstitial fibrosis, leading to renal dysfunction. Chicory extract (hereafter referred to as chicory) clearly reduced serum uric acid levels in rats with HUA induced by 10% fructose. This is the first study to observe the effect of chicory on serum uric acid levels and renal function in rats with HUA and renal injury. In vivo studies using hyperuricaemic rats with renal injury induced by yeast and adenine demonstrated that chicory decreased serum uric acid level, and its effect of delaying the progression of kidney injury was better than that of benzbromarone. In vitro cell experiments showed that this effect is related to the inhibition of GLUT9 protein expression in renal tubules and that lowering blood uric acid concentrations is one of the factors that alleviates renal damage. The results of this study indicate that chicory can be used as an alternative for alleviating renal dysfunction in hyperuricaemia.