Increased loss of the Y chromosome in peripheral blood cells in male patients with autoimmune thyroiditis
Increased loss of the Y chromosome in peripheral blood cells in male patients with autoimmune thyroiditis
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DOI：
10.1016/j.jaut.2011.11.011
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发表时间：
2012-05-01
影响因子：
12.8
通讯作者：
Invernizzi, Pietro
中科院分区：
文献类型：
--
作者：
Persani, Luca;Bonomi, Marco;Invernizzi, Pietro
多种机制已被提出来解释女性和男性中自身免疫性甲状腺炎（AIT）的特殊分布。大多数注意力都集中在雌激素和X染色体的作用的检测。具体而言，X单倍不足的潜在作用已在女性患者人群中提出，并已证实与疾病的关联。然而，我们对男性患者自身免疫发病机制的认识仍然有限。除了雄激素及其失衡的可能作用外，Y染色体似乎是影响男性免疫功能的潜在候选者。在此，我们分析了AIT男性患者（n = 31）和健康对照组（n = 88）的人群，以确定疾病和Y染色体丢失的潜在关联。与未受影响的受试者相比，AIT中的Y染色体丢失增加;如预期的，这些现象随着年龄的增长而增加，然而，与健康对照相比，患者群体中的丢失程度显著增加。因此，我们能够证实在男性人群中存在类似的机制，以前确定的X单倍不足的女性患者与AIT。我们认为这种共性可能代表了AIT发病机制中的一个相关特征，应该进一步研究。(C)2011爱思唯尔有限公司版权所有。
Multiple mechanisms have been proposed to explain the peculiar distribution of autoimmune thyroiditis (AIT) among women and men. Most attention has been focused on the detection of the role of estrogens and the X chromosome. Specifically, a potential role for X haploinsufficiency has been proposed in the female patient population and an association with the disease has been confirmed. Our knowledge of the etiopathogenesis of autoimmunity in male patients remains, however, limited. Next to the possible role of androgens and their imbalances, the Y chromosome appears as a potential candidate for influence of the immune function in men. Herein we analyzed a population of male patients with AIT (n = 31) and healthy controls (n = 88) to define a potential association of disease and the loss of the Y chromosome. Y chromosome loss increases in AIT compared to unaffected subjects; these phenomenon increases with aging as expected, however, the degree of loss is significantly increased in the patient population compared to the healthy controls. We were, thus, able to confirm the existence of an analogous mechanism in the male population to previously identified X haploinsufficiency in female patients with AIT. We propose that this commonality might represent a relevant feature in the etiopathogenesis of AIT that should be further investigated. (C) 2011 Elsevier Ltd. All rights reserved.