RISK OF BREAST-CANCER IN RELATION TO CIGARETTE-SMOKING
RISK OF BREAST-CANCER IN RELATION TO CIGARETTE-SMOKING
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DOI：
10.1001/archinte.148.1.140
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发表时间：
1988-01-01
影响因子：
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通讯作者：
PAPERMASTER, BW
中科院分区：
文献类型：
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作者：
BROWNSON, RC;BLACKWELL, CW;PAPERMASTER, BW
为了提供吸烟与乳腺癌相关性的更多数据，在癌症筛查项目的参与者中进行了一项病例对照研究，包括456例乳腺癌病例和1693例匹配对照。目前吸烟者的乳腺癌校正风险为1.38（95%置信区间为1.01至1.90）。对绝经前妇女吸烟习惯的分析显示，目前吸烟者的风险估计值为2.33（置信区间为1.10至4.96），每天吸烟数量和吸烟年数的风险呈线性增加趋势。虽然吸烟者比不吸烟者有更早的自然绝经，但在调整其他因素后，没有证据表明早期绝经具有保护作用。这些研究结果表明，吸烟可能会增加乳腺癌的发病率，特别是在绝经前妇女。
To provide additional data on the smoking-breast cancer association, a case-control study of 456 cases of breast cancer and 1693 matched controls was conducted among participants in a cancer screening program. The adjusted risk of breast cancer for current smokers was 1.38 (95% confidence interval, 1.01 to 1.90). Analysis of smoking habits restricted to premenopausal women revealed a risk estimate of 2.33 (confidence interval, 1.10 to 4.96) among current smokers and increasing linear trends in risk for number of cigarettes smoked per day and for number of years of smoking. Although smokers had an earlier natural menopause than nonsmokers, there was no evidence of a protective effect of early menopause after adjustment for other factors. These findings suggest that smoking may increase the incidence of breast cancer, especially in premenopausal women.