Dietary supplementation of L-carnosine prevents ischemia/reperfusion-induced renal injury in rats (Retracted article. See vol. 37, pg. 1080, 2014)
Dietary supplementation of L-carnosine prevents ischemia/reperfusion-induced renal injury in rats (Retracted article. See vol. 37, pg. 1080, 2014)
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DOI：
10.1248/bpb.28.361
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发表时间：
2005-02-01
影响因子：
2
通讯作者：
Matsumura, Y
中科院分区：
文献类型：
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作者：
Fujii, T;Takaoka, M;Matsumura, Y
研究了膳食补充 L-肌肽（β-丙氨酰-L-组氨酸）对大鼠缺血/再灌注诱发的急性肾衰竭 (ARF) 的影响。对侧肾切除术后 2 周，左肾动脉和静脉闭塞 45 分钟，然后再灌注，诱发缺血性 ARF。测量肾功能参数，如血尿素氮、血浆肌酐、肌酐清除率、尿流量、尿渗透压和钠排泄分数。 ARF大鼠的肾功能在再灌注后1天明显下降。预先饲喂含 L-肌肽 (0.0001 w/w%) 两周可减轻缺血/再灌注引起的肾功能障碍。 ARF大鼠肾脏的组织病理学检查显示严重的肾损伤，例如肾小管坏死、肾小管中的蛋白质管型和髓质充血，这些损伤也通过膳食补充L-肌肽而显着抑制。这些发现强烈表明，补充 L(-) 肌肽可作为缺血性 ARF 发展的预防性治疗。
The effects of dietary supplementation of L-carnosine (beta-alanyl-L-histidine) on ischemia/reperfusion-induced acute renal failure (ARF) in rats were examined. Ischemic ARF was induced by occlusion of the left renal artery and vein for 45 min followed by reperfusion, 2 weeks after contralateral nephrectomy. Renal functional parameters such as blood urea nitrogen, plasma creatinine, creatinine clearance, urine flow, urinary osmolality and fractional excretion of sodium were measured. Renal function in ARF rats markedly decreased at 1 d after reperfusion. Prior feeding of L-carnosine-containing diet (0.0001 w/w%) for 2 weeks attenuated the ischemia/reperfusion-induced renal dysfunction. Histopathological examination of the kidney of ARF rats revealed severe renal damages, such as tubular necrosis, proteinaceous casts in tubuli and medullary congestion, which were also significantly suppressed by the dietary supplementation Of L-carnosine. These findings strongly suggest that L(-)carnosine supplementation is useful as a prophylactic treatment in the development of the ischemic ARF.