SENSORY IRRITATION TOLERANCE AND CROSS-TOLERANCE IN F344 RATS EXPOSED TO CHLORINE OR FORMALDEHYDE GAS
SENSORY IRRITATION TOLERANCE AND CROSS-TOLERANCE IN F344 RATS EXPOSED TO CHLORINE OR FORMALDEHYDE GAS
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DOI：
10.1016/0041-008x(84)90013-9
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发表时间：
1984-01-01
影响因子：
3.8
通讯作者：
BARROW, CS
中科院分区：
文献类型：
--
作者：
CHANG, JCF;BARROW, CS
吸入Cl2或HCHO刺激鼻黏膜三叉神经末梢，导致呼吸频率呈浓度依赖性降低。通过比较初生大鼠和预暴露于Cl2或HCHO的大鼠呼吸抑制的浓度-反应曲线，确定其耐受和交叉耐受。Cl2耐受性的发展与时间和浓度有关，在暴露于10ppm下1天（6小时/天）后显著，并在4天达到最大值。在2.5 ppm Cl2下，耐受性仅在暴露10天后才显着。对Cl2耐受的大鼠对HCHO也表现出交叉耐受。在暴露于28 ppm 4天的大鼠中观察到对HCHO的耐受性，但在暴露于15 ppm 1、4或10天的组中则没有。暴露于15ppm HCHO 1天后，对Cl2的交叉耐受性显著，暴露10天后效果最大。暴露4天后，耐受性在7天后恢复。交叉耐受性也有所降低，但程度较轻。这些结果提示了Cl2和HCHO的耐受性和交叉耐受性发展的共同机制，但在三叉神经末梢可能存在不同的反应位点。
Inhalation of Cl2 or HCHO stimulated the trigeminal nerve endings in the nasal mucosa and resulted in respiratory rate depression in a concentration-dependent manner. To determine tolerance and cross-tolerance, the concentration-response curves of respiratory depression were compared between naive rats and rats pre-exposed to Cl2 or HCHO. Cl2 tolerance development was time and concentration dependent, being significant following a 1 day (6 h/day), 10 ppm exposure, and reaching the maximum in 4 days. At 2.5 ppm Cl2, tolerance was significant only after 10 days of exposure. Rats tolerant to Cl2 also showed cross-tolerance to HCHO. Tolerance to HCHO was observed in rats exposed to 28 ppm for 4 days, but not in groups exposed to 15 ppm for 1, 4 or 10 days. Significant cross-tolerance to Cl2 was evident following a 1 day exposure to 15 ppm HCHO, with greatest effect seen in the group exposed for 10 days. Tolerance was reduced after a 7 day recovery following a 4 day exposure. Cross-tolerance was reduced also, but to a lesser extent. These results suggested a common mechanism for tolerance and cross-tolerance development, but different reactive sites may have existed for Cl2 and HCHO at the trigeminal nerve endings.