The fission yeast TOR proteins and the rapamycin response: an unexpected tale.
The fission yeast TOR proteins and the rapamycin response: an unexpected tale.
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裂殖酵母 TOR 蛋白和雷帕霉素反应：一个意想不到的故事。
DOI：
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发表时间：
2004
影响因子：
--
通讯作者：
R. Weisman
中科院分区：
文献类型：
--
作者：
R. Weisman
TOR蛋白被认为是响应营养和促有丝分裂信号的细胞生长的关键调节因子，也是免疫抑制和抗癌药物雷帕霉素的靶点。裂殖酵母裂殖酵母有两个TOR同源物，tor1+和tor2+。尽管它们的结构相似，但这些基因具有不同的功能：tor1+在饥饿，极端温度和渗透或氧化应激条件下是必需的，而tor2+在正常生长条件下是必需的。令人惊讶的是，雷帕霉素似乎没有抑制S。pombe TOR相关功能。雷帕霉素特异性抑制S. pombe，这似乎源于S.粟酒FKBP 12同源物。为什么是S。粟酒裂殖酵母细胞在生长期对雷帕霉素具有抗性的原因尚不清楚，并等待对TOR依赖性信号传导途径的进一步分析。
The TOR proteins are known as key regulators of cell growth in response to nutritional and mitogenic signals and as targets for the immunosuppressive and anti-cancerous drug rapamycin. The fission yeast Schizosaccharomyces pombe has two TOR homologues, tor1+ and tor2+. Despite their structural similarity, these genes have distinct functions: tor1+ is required under starvation, extreme temperatures, and osmotic or oxidative stress conditions, whereas tor2+ is required under normal growth conditions. Surprisingly, rapamycin does not seem to inhibit the S. pombe TOR-related functions. Rapamycin specifically inhibits sexual development in S. pombe, and this seems to stem from direct inhibition of the S. pombe FKBP12 homologue. Why S. pombe cells are resistant to rapamycin during the growth phase is as yet unclear and awaits further analysis of the TOR-dependent signaling pathways.
影响因子：
5.6
作者：
VANDUYNE, GD;STANDAERT, RF;CLARDY, J
通讯作者：
CLARDY, J
DOI：
10.1073/pnas.92.11.4947
发表时间：
1995-05-23
影响因子：
11.1
作者：
CHEN, J;ZHENG, XF;SCHREIBER, SL
通讯作者：
SCHREIBER, SL