Creatine kinase activities in brain and blood:possible neurotoxic indicator of acrylamide intoxication.
Creatine kinase activities in brain and blood:possible neurotoxic indicator of acrylamide intoxication.
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大脑和血液中的肌酸激酶活性：丙烯酰胺中毒的可能神经毒性指标。
DOI：
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发表时间：
1996
影响因子：
4.9
通讯作者：
H. Igisu
中科院分区：
文献类型：
--
作者：
M. Matsuoka;H. Matsumura;H. Igisu
检查肌酸激酶（CK）活性是否与丙烯酰胺引起的神经功能障碍相关。方法--测定丙烯酰胺中毒小鼠和大鼠脑和血浆中CK和其他被丙烯酰胺抑制的酶的活性，以及着陆足伸展（LFS）。结果：丙烯酰胺抑制小鼠脑内CK活性，同时LFS测定神经功能障碍。在实验期间（暴露8天，恢复43天），甘油醛-3-磷酸脱氢酶、神经元特异性烯醇化酶和乳酸脱氢酶活性没有明显变化。在大鼠中，在检查的血浆酶中，CK活性的抑制最明显，但甲状腺活性不受影响。结论：在迄今为止检测的酶中，脑和血液中的CK活性似乎是丙烯酰胺中毒的最敏感指标。
OBJECTIVES--To examine whether the activities of creatine kinase (CK) correlate with neurological disturbances caused by acrylamide. METHODS--The activities of CK and other enzymes reported to be inhibited by acrylamide in the brain and plasma, and landing foot spread (LFS) were measured in mice and rats intoxicated with acrylamide. RESULTS--Activity of CK was suppressed by acrylamide in the brain of mice in parallel with the neurological dysfunction measured by LFS. No clear alterations were found in glyceraldehyde-3-phosphate dehydrogenase, neuron-specific enolase, and lactate dehydrogenase activities over the experimental period (eight days for the exposure and 43 days for the recovery). In rats, among the plasma enzymes examined, suppression of CK activity was most notable, but thyroid activity was not affected. CONCLUSIONS--Among the enzymes so far examined, the CK activities in the brain and blood seem to be the most sensitive indicators of acrylamide intoxication.
丙烯酰胺神经病的病因：丙烯酰胺中毒猫的周围神经、脊髓、大脑和骨骼肌中的烯醇化酶、磷酸果糖激酶和甘油醛-3-磷酸脱氢酶活性。
影响因子：
3.8
作者：
Howland,RD
通讯作者：
Howland,RD