Psoriasis and Hypertension: A Case-Control Study
Psoriasis and Hypertension: A Case-Control Study
复制标题
DOI：
10.2340/00015555-0741
复制
发表时间：
2010-01-01
影响因子：
3.6
通讯作者：
Dreiher, Jacob
中科院分区：
文献类型：
--
作者：
Cohen, Arnon D.;Weitzman, Dahlia;Dreiher, Jacob
近年来，大量报告证明牛皮癣与代谢综合征之间存在关联。然而，一些研究未能证明牛皮癣和高血压之间存在关联。本研究的目的是检查牛皮癣和高血压之间的关联。在一项病例对照研究中，对健康维护组织的银屑病患者与未患银屑病的参与者进行了高血压患病率的比较。该研究包括 12,502 名 20 岁以上的银屑病患者和 24,285 名年龄和性别频率匹配的对照者。银屑病患者的高血压患病率显着高于对照组（分别为 38.8%、29.1%，p < 0.001）。在多变量分析中，在控制了年龄、性别、吸烟状况、肥胖、糖尿病、非甾体抗炎药 (NSAID) 和 Cox-2 抑制剂的使用后，高血压与银屑病相关（比值比：1.37，95% 置信区间：1.29-1.46）。这项研究的结果支持了先前指出的牛皮癣和高血压之间的关联。我们建议银屑病患者应常规筛查是否存在高血压。
In recent years, numerous reports have demonstrated an association between psoriasis and metabolic syndrome. However, some studies failed to demonstrate an association between psoriasis and hypertension. The aim of the present study was to examine the association between psoriasis and hypertension. Psoriasis patients of a health-maintenance organization were compared with enrollees without psoriasis regarding the prevalence of hypertension in a case-control study. The study included 12,502 psoriasis patients over the age of 20 years and 24,285 age- and sex-frequency-matched controls. The prevalence of hypertension was significantly higher in psoriasis patients than controls (38.8%, 29.1%, respectively, p < 0.001). In a multivariate analysis, hypertension was associated with psoriasis after controlling for age, sex, smoking status, obesity, diabetes, non-steroidal anti-inflammatory drugs (NSAIDs) and use of Cox-2 inhibitors (odds ratio: 1.37, 95% confidence interval: 1.29-1.46). The results of this study support the previously noted association between psoriasis and hypertension. We suggest that patients with psoriasis should be routinely screened for the presence of hypertension.