Aberrant DNA methylation profiles in the premature aging disorders Hutchinson-Gilford Progeria and Werner syndrome.
Aberrant DNA methylation profiles in the premature aging disorders Hutchinson-Gilford Progeria and Werner syndrome.
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DOI：
10.4161/epi.23366
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发表时间：
2013-01
期刊：
影响因子：
3.7
通讯作者：
Esteller M
中科院分区：
文献类型：
--
作者：
Heyn H;Moran S;Esteller M
DNA methylation gradiently changes with age and is likely to be involved in aging-related processes with subsequent phenotype changes and increased susceptibility to certain diseases. The Hutchinson-Gilford Progeria (HGP) and Werner Syndrome (WS) are two premature aging diseases showing features of common natural aging early in life. Mutations in the LMNA and WRN genes were associated to disease onset; however, for a subset of patients the underlying causative mechanisms remain elusive. We aimed to evaluate the role of epigenetic alteration on premature aging diseases by performing comprehensive DNA methylation profiling of HGP and WS patients. We observed profound changes in the DNA methylation landscapes of WRN and LMNA mutant patients, which were narrowed down to a set of aging related genes and processes. Although of low overall variance, non-mutant patients revealed differential DNA methylation at distinct loci. Hence, we propose DNA methylation to have an impact on premature aging diseases.
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影响因子：
56.9
作者：
Yu, CE;Oshima, J;Schellenberg, GD
通讯作者：
Schellenberg, GD
影响因子：
3.7
作者：
Sandoval, Juan;Heyn, Holger A.;Esteller, Manel
通讯作者：
Esteller, Manel
DOI：
10.1073/pnas.0500398102
发表时间：
2005-07-26
影响因子：
11.1
作者：
Fraga, MF;Ballestar, E;Esteller, M
通讯作者：
Esteller, M
影响因子：
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通讯作者：
Collins, FS
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作者：
Huang, Da Wei;Sherman, Brad T.;Lempicki, Richard A.
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Lempicki, Richard A.