Targeted imaging of neoplasia in the digestive tract.
Targeted imaging of neoplasia in the digestive tract.
复制标题
DOI：
10.3233/cbm-2008-4601
复制
发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Thomas D. Wang
中科院分区：
文献类型：
--
作者：
Thomas D. Wang
在本期《癌症生物标记物》杂志中，我们讨论了用于对消化道肿瘤进行靶向成像的新型分子探针和内窥镜仪器的出现。消化道是开发这些新兴方法的理想场所，特别是在临床应用中，因为这些中空器官很容易通过内窥镜接触到，而且外源性探头可以安全地局部应用。作为一种评估癌症生物标志物的临床工具，成像的作用正变得越来越重要。空间信息为指导组织活检、对危险患者分层、监测治疗反应和评估肿瘤复发提供了强大的资源。此外，我们最近对导致消化道癌细胞克隆选择和生长优势的遗传和分子变化序列有了更多的了解[1-3]。这项研究揭示了关键分子靶点表达的时机，以便我们可以通过成像方法早期检测诊断癌症的生物标志物。我们现在开始看到我们在分子生物学、亲和探针的开发和成像仪器的性能方面的知识趋同。这些因素是相互依赖的，随着我们朝着个性化医学的方向发展，它们必须共同发展[4]。目前，医生主要根据结构异常做出诊断和分期癌症的临床决定。
In this issue of Cancer Biomarkers, we discuss the emergence of novel molecular probes and endoscopic instruments for performing targeted imaging of neoplasia in the digestive tract. The digestive tract is an ideal place to develop these emerging methods, in particular for clinical applications because these hollow organs are easy to access with endoscopy and exogenous probes can be topically applied safely. The role of imaging is becoming ever more important as a clinical tool for assessing cancer biomarkers. Spatial information provides a powerful resource to guide tissue biopsy, stratify risk patients, monitor therapeutic response, and assess tumor recurrence. Moreover, we have recently experienced greater understanding of the sequence of genetic and molecular changes that lead to clonal selection and growth advantages for cancerous cells in the digestive tract [1–3]. This research has revealed the timing of expression of key molecular targets so that we can perform earlier detection of diagnostic cancer biomarkers with imaging methods. We are now beginning to see a convergence in our knowledge of molecular biology, development of affinity probes, and performance of imaging instruments. These factors are interdependent and must develop together as we head in the direction of personalized medicine [4]. Currently, physicians make clinical decisions to diagnose and stage cancer based primarily on structural abnormali-