Early Alzheimer's Disease.
Early Alzheimer's Disease.
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DOI：
10.1056/nejmcp0910236
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发表时间：
2010-06-10
影响因子：
158.5
通讯作者：
Mayeux, Richard
中科院分区：
文献类型：
--
作者：
Mayeux, Richard
一名72岁的男子在妻子的催促下，因过去两年来记忆力越来越困难而寻求咨询。他的经纪公司的客户对他偶尔的失忆表示担忧。他的妻子报告说，他经常重复有关社交约会的问题，当她指出这一点时，他会生气。体格检查是正常的，但是病人在记住一个简短故事的内容方面有困难，在添加少量的变化方面也有困难。怀疑是阿尔茨海默病。该如何评估和治疗该患者？
A 72-year-old man seeks consultation at the urging of his wife for increasing difficulty with memory over the past 2 years. Clients at his brokerage firm have expressed concern about his occasional lapses in memory. His wife reports that he frequently repeats questions about social appointments and becomes angry when she points this out. The physical examination is normal, but the patient has difficulty remembering elements of a brief story and difficulty in adding a small amount of change. Alzheimer's disease is suspected. How should this patient be evaluated and treated?