Peri- and intra-implant bone response to microporous Ti coatings with surface modification
Peri- and intra-implant bone response to microporous Ti coatings with surface modification
复制标题
DOI：
10.1016/j.actbio.2013.10.017
复制
发表时间：
2014-02-01
影响因子：
9.7
通讯作者：
Vleugels, Jozef
中科院分区：
文献类型：
--
作者：
Braem, Annabel;Chaudhari, Amol;Vleugels, Jozef
植入物表面及内部具有大量孔隙的骨生长是一种有前景的策略，旨在改善骨植入物的长期稳定固定。然而，其在临床应用中的可靠性仍是一个有争议的问题。大部分注意力都集中在大孔隙的作用上，从而达成了一个普遍共识，即为使骨长入，最小孔径应为50 - 100微米。在这项体内研究中，我们评估了早期骨长入平均厚度为150微米的主要为微孔的钛涂层的可行性，以及通过对多孔涂层进行表面改性来改善骨反应的假设。将植入物放置在兔胫骨皮质骨中2周和4周，然后使用光学显微镜和扫描电子显微镜进行组织学和组织形态计量学评估。在整个多孔钛涂层直至涂层/基底界面都发现了有骨细胞包埋在矿化基质中的骨，这突出表明微孔的骨整合（最后一个单词不完整，翻译可能会有细微偏差）
Bone growth on and into implants exhibiting substantial surface porosity is a promising strategy in order to improve the long-term stable fixation of bone implants. However, the reliability in clinical applications remains a point of discussion. Most attention has been dedicated to the role of macroporosity, leading to the general consensus of a minimal pore size of 50-100 mu m in order to allow bone ingrowth. In this in vivo study, we assessed the feasibility of early bone ingrowth into a predominantly microporous Ti coating with an average thickness of 150 mu m and the hypothesis of improving the bone response through surface modification of the porous coating. Implants were placed in the cortical bone of rabbit tibiae for periods of 2 and 4 weeks and evaluated histologically and histomorphometrically using light microscopy and scanning electron microscopy. Bone with osteocytes encased in the mineralized matrix was found throughout the porous Ti coating up to the coating/substrate interface, highlighting that osseointegration of microporosities (