A density gradient of basic fibroblast growth factor guides directional migration of vascular smooth muscle cells
A density gradient of basic fibroblast growth factor guides directional migration of vascular smooth muscle cells
复制标题
碱性成纤维细胞生长因子的密度梯度引导血管平滑肌细胞定向迁移
DOI：
10.1016/j.colsurfb.2014.02.043
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Gao Changyou
中科院分区：
文献类型：
--
作者：
Wu Jindan;Mao Zhengwei;Han Lulu;Zhao Yizhi;Xi Jiabin;Gao Changyou
The migration of vascular smooth muscle cells (VSMCs) is an important process in many physiological events. It is of paramount importance to control the migration rate and direction of VSMCs by biomaterials. In this paper, a density gradient of basic fibroblast growth factor (bFGF) was fabricated using an injection method and the bio-conjugation between heparin and bFGF. The density of bFGF gradually increased with a slope of 17 ng/cm2/mm. Adhesion and migration of VSMCs were studied on the bFGF gradient. The VSMCs exhibited preferential orientation and an enhanced directional migration behavior on the gradient surface. Up to 70% cells migrated towards the region with a higher density of bFGF on the gradient. However, the bFGF gradient had no effect on the cell migration rate.
