Bioinspired mononuclear Mn complexes for O 2 activation and biologically relevant reactions
Bioinspired mononuclear Mn complexes for O 2 activation and biologically relevant reactions
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用于 O 2 活化和生物学相关反应的仿生单核锰配合物
DOI：
10.1039/d1dt03178c
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发表时间：
2021
影响因子：
4
通讯作者：
Machan, Charles W.
中科院分区：
文献类型：
--
作者：
Cook, Emma N.;Machan, Charles W.
对利用分子氧（O2）的氧化能力的普遍兴趣继续推动对生物启发和仿生复合物的研究工作，以更好地了解金属酶如何介导这些反应。普遍存在的Fe-和Cu-基酶引起了人们的极大关注，并导致了许多值得注意的发展感兴趣的直接O2还原和小分子活化的非生物系统。然而，尽管存在锰为基础的金属酶具有重要的O2-依赖性的活动，有相对较少的关注这些类似物的发展相对于Fe和Cu系统。在这个角度来看，我们总结了重要的贡献，以发展生物启发单核锰配合物的O2活化和研究其反应性，强调重要的设计参数在初级和次级配位领域，并概述了机械的趋势。
A general interest in harnessing the oxidizing power of dioxygen (O2) continues to motivate research efforts on bioinspired and biomimetic complexes to better understand how metalloenzymes mediate these reactions. The ubiquity of Fe- and Cu-based enzymes attracts significant attention and has resulted in many noteworthy developments for abiotic systems interested in direct O2 reduction and small molecule activation. However, despite the existence of Mn-based metalloenzymes with important O2-dependent activity, there has been comparatively less focus on the development of these analogues relative to Fe- and Cu-systems. In this Perspective, we summarize important contributions to the development of bioinspired mononuclear Mn complexes for O2 activation and studies on their reactivity, emphasizing important design parameters in the primary and secondary coordination spheres and outlining mechanistic trends.