Coincidence of COVID-19 epidemic and olfactory dysfunction outbreak in Iran.
Coincidence of COVID-19 epidemic and olfactory dysfunction outbreak in Iran.
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DOI：
10.34171/mjiri.34.62
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发表时间：
2020
影响因子：
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通讯作者：
Dehghani Firouzabadi F
中科院分区：
文献类型：
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作者：
Bagheri SH;Asghari A;Farhadi M;Shamshiri AR;Kabir A;Kamrava SK;Jalessi M;Mohebbi A;Alizadeh R;Honarmand AA;Ghalehbaghi B;Salimi A;Dehghani Firouzabadi F
背景：新型冠状病毒病2019年(新冠肺炎)期间嗅觉障碍/异物异常症的发生可能表明嗅觉功能障碍与冠状病毒病2019(新冠肺炎)的重合有关。这项研究旨在评估伊朗新冠肺炎疫情期间自我报告的嗅觉缺失/嗅觉减退的频率。方法：这项以人群为基础的横断面研究于2020年3月12日至17日通过在线问卷进行。来自伊朗各省的病例自愿参加了这项研究。患者完成了一份由33个项目的患者报告的在线问卷，包括嗅觉和味觉障碍及其共病，以及他们的基本特征和过去的病史。纳入标准为自伊朗新冠肺炎疫情开始以来的过去4周内自我报告的嗅觉障碍/嗅觉不足。结果：10069名年龄为32.5±8.6(7~78岁)的受试者完成了网络问卷调查，其中女性占71.13%，非吸烟者占81.68%。截至2020年3月17日，所有省份的嗅觉障碍患者数量与报告的新冠肺炎患者之间的相关性非常显著(Spearman相关系数=0.87P<；0.001)。自COVID19流行以来，76.24%的受试者突然出现嗅觉障碍，60.90%的受试者持续嗅觉障碍。此外，80.38%的参与者报告了伴随的嗅觉和味觉功能障碍。结论：在新冠肺炎疫情期间，伊朗发生了嗅觉功能障碍暴发。新冠肺炎患者发生嗅觉缺失/位置低下的确切机制有待进一步研究。
Background: The occurrence of anosmia/hyposmia during novel Coronavirus disease 2019 (COVID-19) may indicate a relationship between coincidence of olfactory dysfunction and coronavirus disease 2019 (COVID-19). This study aimed to assess the frequency of self-reported anosmia/hyposmia during COVID-19 epidemic in Iran. Methods: This population-based cross sectional study was performed through an online questionnaire from March 12 to 17, 2020. Cases from all provinces of Iran voluntarily participated in this study. Patients completed a 33-item patient-reported online questionnaire, including smell and taste dysfunction and their comorbidities, along with their basic characteristics and past medical histories. The inclusion criteria were self-reported anosmia/hyposmia during the past 4 weeks, from the start of COVID-19 epidemic in Iran. Results: A total of 10 069 participants aged 32.5±8.6 (7-78) years took part in this study, of them 71.13% women and 81.68% nonsmokers completed the online questionnaire. The correlation between the number of olfactory disorders and reported COVID-19 patients in all provinces up to March 17, 2020 was highly significant (Spearman correlation coefficient = 0.87, P< 0.001). A sudden onset of olfactory dysfunction was reported in 76.24% of the participations and persistent anosmia in 60.90% from the start of COVID19 epidemic. In addition, 80.38% of participants reported concomitant olfactory and gustatory dysfunctions. Conclusion: An outbreak of olfactory dysfunction occurred in Iran during the COVID-19 epidemic. The exact mechanisms by which anosmia/hyposmia occurred in patients with COVID-19 call for further investigations.