Mimecan, a Hormone Abundantly Expressed in Adipose Tissue, Reduced Food Intake Independently of Leptin Signaling.
Mimecan, a Hormone Abundantly Expressed in Adipose Tissue, Reduced Food Intake Independently of Leptin Signaling.
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Mimecan 是一种在脂肪组织中大量表达的激素，可独立于瘦素信号减少食物摄入量
DOI：
10.1016/j.ebiom.2015.09.044
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发表时间：
2015-11
期刊：
影响因子：
11.1
通讯作者：
Song HD
中科院分区：
文献类型：
--
作者：
Cao HM;Ye XP;Ma JH;Jiang H;Li SX;Li RY;Li XS;Guo CC;Wang ZQ;Zhan M;Zuo CL;Pan CM;Zhao SX;Zheng CX;Song HD
瘦素等脂肪因子在能量代谢的调节中起重要作用，特别是在食欲的控制中。在这里，我们描述了一种激素，mimecan，这是丰富的脂肪组织中表达。观察到Mimecan抑制小鼠的食物摄入并降低体重。腹腔注射mimecan-麦芽糖结合蛋白（-MBP）复合物抑制C57 BL/6 J小鼠的摄食，这是减弱预处理与多克隆抗体对mimecan。值得注意的是，mimecan-MBP还在Ay/a和db/db小鼠中诱导厌食症。此外，mimecan-MBP可上调下丘脑中白细胞介素（IL）-1β和IL-6的表达，重组小鼠mimecan可上调N9小胶质细胞中IL-1 β和IL-6的表达。总之，结果表明mimecan是脂肪组织中的饱腹激素，并且mimecan通过诱导下丘脑中的IL-1β和IL-6表达来独立于瘦素信号传导抑制食物摄入。
Adipokines such as leptin play important roles in the regulation of energy metabolism, particularly in the control of appetite. Here, we describe a hormone, mimecan, which is abundantly expressed in adipose tissue. Mimecan was observed to inhibit food intake and reduce body weight in mice. Intraperitoneal injection of a mimecan-maltose binding protein (-MBP) complex inhibited food intake in C57BL/6J mice, which was attenuated by pretreatment with polyclonal antibody against mimecan. Notably, mimecan-MBP also induced anorexia in Ay/a and db/db mice. Furthermore, the expression of interleukin (IL)-1β and IL-6 was up-regulated in the hypothalamus by mimecan-MBP, as well as in N9 microglia cells by recombinant mouse mimecan. Taken together, the results suggest that mimecan is a satiety hormone in adipose tissue, and that mimecan inhibits food intake independently of leptin signaling by inducing IL-1β and IL-6 expression in the hypothalamus.