THE EFFERENT PROJECTIONS OF THE PERIAQUEDUCTAL GRAY IN THE RAT - A PHASEOLUS-VULGARIS-LEUKOAGGLUTININ STUDY .1. ASCENDING PROJECTIONS
THE EFFERENT PROJECTIONS OF THE PERIAQUEDUCTAL GRAY IN THE RAT - A PHASEOLUS-VULGARIS-LEUKOAGGLUTININ STUDY .1. ASCENDING PROJECTIONS
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DOI：
10.1002/cne.903510407
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发表时间：
1995-01-23
影响因子：
2.5
通讯作者：
WILLIS, WD
中科院分区：
文献类型：
--
作者：
CAMERON, AA;KHAN, IA;WILLIS, WD
本研究观察了大鼠中脑导水管周围灰质的上行投射。注射菜豆-白细胞凝集素被放置在背外侧或腹外侧亚区，在吻或尾网站。从这两个区域，纤维通过两束上升。脑室周围束在导水管周围和脑室周围灰质内上行。在后连合水平，这束分为背侧组件，终止于板内和中线丘脑核，和腹侧组件，供应下丘脑。腹侧束形成于中脑深部网状结构，供应腹侧被盖区、黑质腹侧部和红核后野。其余纤维并入内侧前脑束。背外侧亚区主要支配丘脑中央外侧核、室旁核和下丘脑前区。腹外侧亚区优先支配丘脑束旁核和中央内侧核、下丘脑外侧区和终纹床核外侧部。虽然背外侧和腹外侧亚区产生了差异的预测，从任何一个亚区的喙部和尾部的预测是相似的。这表明背外侧和腹外侧亚区被组织成纵向柱，延伸到整个长度的导水管周围灰质。这些列可能对应于最近的生理学研究中证明的那些列。(C)1995 Wiley-Liss，Inc.
This study has examined the ascending projections of the periaqueductal gray in the rat. Injections of Phaseolus vulgaris-leucoagglutinin were placed in the dorsolateral or ventrolateral subregions, at rostral or caudal sites. From either region, fibers ascended via two bundles. The periventricular bundle ascended in the periaqueductal and periventricular gray matter. At the posterior commissure level, this bundle divided into a dorsal component that terminated in the intralaminar and midline thalamic nuclei, and a ventral component that supplied the hypothalamus. The ventral bundle formed in the deep mesencephalic reticular formation and supplied the ventral tegmental area, substantia nigra pars compacta, and the retrorubral field. The remaining fibers were incorporated into the medial forebrain bundle. These supplied the lateral hypothalamus and forebrain structures, including the preoptic area, the nuclei of the diagonal band, and the lateral division of the bed nucleus of the stria terminalis.The dorsolateral subregion preferentially innervated the centrolateral and paraventricular thalamic nuclei and the anterior hypothalamic area. The ventrolateral subregion preferentially innervated the parafascicular and central medial thalamic nuclei, the lateral hypothalamic area, and the lateral division of the bed nucleus of the stria terminalis. Although the dorsolateral and ventrolateral subregions gave rise to differential projections, the projections from both the rostral and caudal parts of either subregion were similar. This suggests that the dorsolateral and ventrolateral subregions are organized into longitudinal columns that extend throughout the length of the periaqueductal gray. These columns may correspond to those demonstrated in recent physiological studies. (C) 1995 Wiley-Liss, Inc.