Regulation of NF-κB by the CARD proteins.
Regulation of NF-κB by the CARD proteins.
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DOI：
10.1111/j.1600-065x.2012.01110.x
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发表时间：
2012-03
影响因子：
8.7
通讯作者：
Lin X
中科院分区：
文献类型：
--
作者：
Jiang C;Lin X
支架蛋白通过连接上游受体和下游效应分子，在信号转导通路的调控中发挥关键作用。在过去的十年中，许多含有caspase-募集结构域（CARD）的支架蛋白已经被鉴定出来。对CARD蛋白作用的研究表明，许多CARD蛋白在导致核因子-κB （NF-κB）活化的信号级联反应中起着至关重要的作用。在这篇综述中，我们讨论了CARD蛋白在各种信号级联中对NF-κB激活的贡献。特别地，我们分享了一些我们在CARD蛋白CARMA家族功能的初步研究中的个人经验，然后总结了这些蛋白在抗原受体、G蛋白偶联受体、受体酪氨酸激酶和c型凝集素受体诱导的信号通路中的作用。
Scaffold proteins play pivotal roles in the regulation of signal transduction pathways by connecting upstream receptors to downstream effector molecules. During last decade, many scaffold proteins that contain caspase-recruitment domain (CARD) have been identified. Investigating the roles of CARD proteins has revealed that many play crucial roles in signaling cascades that lead to activation of nuclear factor-κB (NF-κB). In this review, we discuss the contributions of CARD proteins to NF-κB activation in various signaling cascades. In particular, we share some of our personal experiences during the initial investigation of the functions of the CARMA family of CARD proteins and then summarize the roles of these proteins in signaling pathways induced by antigen receptors, G protein-coupled receptors, receptor tyrosine kinase, and C-type lectin receptors in the context of recent progress in the field.