Serum and Urinary Interferon-Gamma-Inducible Protein 10 in Lupus Nephritis
Serum and Urinary Interferon-Gamma-Inducible Protein 10 in Lupus Nephritis
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DOI：
10.1002/jcla.21993
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发表时间：
2016-11-01
影响因子：
2.7
通讯作者：
Nasef, Samah Ismail
中科院分区：
文献类型：
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作者：
El-Gohary, Ahmed;Hegazy, Ann;Nasef, Samah Ismail
狼疮性肾炎（Lupus nephropathy，LN）是系统性红斑狼疮（systemic lupus erythematosus，SLE）的一种严重表现。本研究的目的是确定IP-10的灵敏度，特异性和截止值的狼疮性肾炎患者的血清和尿液相比，肾活检，白蛋白/肌酐比值，血清抗dsDNA.MethodsThirty女性SLE患者。计算SLEDAI，并收集血液和尿液样本。患者分为10例SLE患者肾脏受累（6个活动和4个非活动），10个活动性SLE，和10个非活动性SLE患者。包括10名年龄匹配的健康（对照）。通过ELISA测量血清和尿IP-10水平。结果活动期SLE患者血、尿IP-10水平均显著高于非活动期SLE患者（P = 0. 015，P = 0. 033）。然而，活动性肾病和活动性非肾病患者的血清和尿液水平没有差异。白蛋白/肌酐比值是鉴别狼疮性肾炎和无肾脏受累的SLE的较好指标。任何血清和尿IP-10，白蛋白/肌酐比值，和抗dsDNA没有相关的狼疮性肾炎的肾biopsiz.Conclusionurinary和血清IP-10的类狼疮活动的有用的标志物，但不指示肾活动。白蛋白/肌酐比值在鉴别狼疮性肾炎和肾活动方面具有上级优势。
BackgroundLupus nephritis is a serious manifestation of systemic lupus erythematosus (SLE). The objective of this study was to identify the sensitivity, specificity, and cut-off values of IP-10 in the serum and urine of patients with lupus nephritis compared to renal biopsy, albumin/creatinine ratio, and serum anti-dsDNA.MethodsThirty female SLE patients were included. SLEDAI was calculated and blood and urine samples were collected. Patients were divided into 10 SLE patients with renal involvement (six active and four inactive), 10 active SLE, and 10 inactive SLE patients. Ten age-matched healthy (control) were included. Serum and urinary levels of IP-10 were measured by ELISA. Anti-dsDNA, urine albumin/creatinine ratio were performed.ResultsSerum and urinary IP-10 in active SLE patients had significantly increased levels as compared to inactive SLE patients (P = 0.015, P = 0.033, respectively). However, there was no difference in serum and urinary levels between active renal and active non-renal patients. Albumin/creatinine ratio is a better marker in differentiating between lupus nephritis and SLE with no renal involvement. Any of serum and urinary IP-10, albumin/creatinine ratio, and anti-dsDNA did not correlate with the class of lupus nephritis in renal biopsy.ConclusionUrinary and serum IP-10 are useful markers of lupus activity, but not indicative of renal activity. Albumin/creatinine ratio is superior in identifying lupus nephritis and renal activity.