Emerging Role of MicroRNA-30c in Neurological Disorders.
Emerging Role of MicroRNA-30c in Neurological Disorders.
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MicroRNA-30c 在神经系统疾病中的新作用
DOI：
10.3390/ijms24010037
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发表时间：
2022-12-20
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
microRNAs（miRNAs或miRs）是一类非编码小分子RNA，通过与靶mRNA的3′端非翻译区相互作用，诱导mRNA降解和翻译抑制，从而负调控靶基因的表达。miR-30家族成员参与许多组织和器官的发育，并参与人类疾病的发病机制。作为miR-30家族的关键成员，miR-30 c与神经系统疾病如阿尔茨海默病、帕金森病、多发性硬化和中风有关。从机制上讲，miR-30 c可以作为不同致病过程的多功能调节剂，例如自噬、凋亡、内质网应激、炎症、氧化应激、血栓形成和神经血管功能，从而促成不同的疾病状态。本文就miR-30 c的生物起源、基因调控、作用机制及其在神经系统疾病中的临床应用前景进行综述和讨论。
MicroRNAs (miRNAs or miRs) are a class of small non-coding RNAs that negatively regulate the expression of target genes by interacting with 3′ untranslated regions of target mRNAs to induce mRNA degradation and translational repression. The miR-30 family members are involved in the development of many tissues and organs and participate in the pathogenesis of human diseases. As a key member of the miR-30 family, miR-30c has been implicated in neurological disorders such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and stroke. Mechanistically, miR-30c may act as a multi-functional regulator of different pathogenic processes such as autophagy, apoptosis, endoplasmic reticulum stress, inflammation, oxidative stress, thrombosis, and neurovascular function, thereby contributing to different disease states. Here, we review and discuss the biogenesis, gene regulation, and the role and mechanisms of action of miR-30c in several neurological disorders and therapeutic potential in clinics.
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影响因子：
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作者：
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通讯作者：
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DOI：
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发表时间：
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发表时间：
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影响因子：
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