Threespine Stickleback: A Model System For Evolutionary Genomics.
Threespine Stickleback: A Model System For Evolutionary Genomics.
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DOI：
10.1146/annurev-genom-111720-081402
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发表时间：
2021-08-31
影响因子：
8.7
通讯作者：
Veeramah KR
中科院分区：
文献类型：
--
作者：
Reid K;Bell MA;Veeramah KR
海洋三刺鱼对淡水的反复适应使其成为研究平行进化的首要生物。这些小鱼有多种不同的生态类型，表现出广泛的不同的表型特征。生态型很容易在实验室中交叉，家庭规模大，发展迅速，足以进行数量性状位点分析，定位threespine刺鱼作为一个多功能的模式生物，以解决广泛的生物学问题。广泛的基因组资源，包括连锁图谱，高质量的参考基因组，和发育遗传学工具，导致深入了解适应的基因组基础和确定控制脊椎动物性状的基因组变化。最近，三刺鱼已被用作模型系统，以确定高度复杂的性状，如行为和宿主-微生物组和宿主-寄生虫相互作用的基因组基础。我们回顾了最新的发现和新的研究途径，导致threespine刺鱼被认为是进化基因组学的超级模型。
The repeated adaptation of oceanic threespine sticklebacks to fresh water has made it a premier organism to study parallel evolution. These small fish have multiple distinct ecotypes that display a wide range of diverse phenotypic traits. Ecotypes are easily crossed in the laboratory, and families are large and develop quickly enough for quantitative trait locus analyses, positioning the threespine stickleback as a versatile model organism to address a wide range of biological questions. Extensive genomic resources, including linkage maps, a high-quality reference genome, and developmental genetics tools have led to insights into the genomic basis of adaptation and the identification of genomic changes controlling traits in vertebrates. Recently, threespine sticklebacks have been used as a model system to identify the genomic basis of highly complex traits, such as behavior and host–microbiome and host–parasite interactions. We review the latest findings and new avenues of research that have led the threespine stickleback to be considered a supermodel of evolutionary genomics.
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影响因子：
16.8
作者：
Bengston, Sarah E;Dahan, Romain A;Donaldson, Zoe;Phelps, Steven M;van Oers, Kees;Sih, Andrew;Bell, Alison M
通讯作者：
Bell, Alison M
影响因子：
3.3
作者：
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通讯作者：
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影响因子：
2
作者：
Bell, M. A.
通讯作者：
Bell, M. A.
影响因子：
3.3
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通讯作者：
Cresko, William A.
影响因子：
2.4
作者：
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通讯作者：
Scharsack, J. P.