Reduced heart rate variability predicts poor sleep quality in a case-control study of chronic fatigue syndrome
Reduced heart rate variability predicts poor sleep quality in a case-control study of chronic fatigue syndrome
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DOI：
10.1007/s00221-010-2296-1
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发表时间：
2010-07-01
影响因子：
2
通讯作者：
Vollmer-Conna, U.
中科院分区：
文献类型：
--
作者：
Burton, A. R.;Rahman, K.;Vollmer-Conna, U.
副交感神经功能在诱导和维持睡眠中起重要作用。我们研究了夜间迷走神经心率调节是否与慢性疲劳综合征（CFS）中常见的睡眠质量差有关。连续监测20例CFS患者和20例匹配对照者睡眠期间的心率（HR， R-R间隔）。问卷评估了人口统计信息、症状、功能损害和主观睡眠质量。总体而言，CFS与研究夜间更多的睡眠问题和较差的主观睡眠质量相关（均p < 0.003），夜间反复醒来的可能性是健康受试者的7倍（p = 0.017）。CFS患者睡眠时心率变异性的时域和频域参数均显著降低（p < 0.006）。多元回归分析显示，心率变异性（HRV）参数是主观睡眠测量的最佳预测指标。这项研究确定了CFS患者睡眠期间迷走神经心率调节的显著减少。低HRV强烈预测睡眠质量-提示CFS患者普遍存在夜间交感神经过度警觉状态。
Parasympathetic function is important in the induction and maintenance of sleep. We examined whether nocturnal vagal modulation of heart rate is related to the poor sleep quality commonly reported in chronic fatigue syndrome (CFS). Heart rate (HR, as R-R intervals) was continuously monitored during sleep in 20 patients with CFS and 20 matched control subjects. Questionnaires assessed demographic information, symptoms, functional impairment, and subjective sleep quality. CFS was associated with more sleep problems in general and poorer subjective sleep quality on the study night (all p < 0.003), and reports of repeated awakening during the night were 7 times more likely compared to healthy subjects (p = 0.017). Time and frequency-domain parameters of HR variability during sleep were significantly lower in patients with CFS (all p < 0.006). Multiple regression analyses revealed that heart rate variability (HRV) parameters were the best predictors of subjective sleep measures. This study identified significant reductions in vagal modulation of heart rate during sleep in CFS. Low HRV strongly predicted sleep quality-suggesting a pervasive state of nocturnal sympathetic hypervigilance in CFS.