Paeonol ameliorates murine alcohol liver disease via mycobiota-mediated Dectin-1/IL-1β signaling pathway
Paeonol ameliorates murine alcohol liver disease via mycobiota-mediated Dectin-1/IL-1β signaling pathway
复制标题
丹皮酚通过真菌介导的 Dectin-1/IL-1 信号通路改善小鼠酒精性肝病
DOI：
10.1002/jlb.3ma0120-325rr
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发表时间：
2020-07-01
影响因子：
5.5
通讯作者：
Yan, Guiming
中科院分区：
文献类型：
--
作者：
Wu, Jiadi;Wu, Daqiang;Yan, Guiming
酒精性肝病（ALD）是由长期饮酒引起的疾病，已成为一个重要的社会和医学问题。肠道真菌菌群（mycobiota）在ALD中起重要作用，因此我们以真菌菌群为切入点，探讨丹皮酚抗ALD的作用机制。本研究发现丹皮酚可有效对抗ALD炎性病变，减轻肝脏脂肪病变。此外，我们发现丹皮酚处理后，真菌生态失调得到改善，真菌丰度降低，β -葡聚糖向肝脏转运及其介导的Dectin-1/IL-1 β信号通路被阻断。我们的研究表明，丹皮酚通过减轻肠道真菌生态失调和抑制真菌菌群介导的Dectin-1/IL-1 β信号通路，改善急性ald相关的肝脏炎症损伤。
Alcoholic liver disease (ALD) is caused by long-term consumption of alcohol and has become an important social and medical problem. Intestinal fungal flora (mycobiota) play an important role in ALD, so we used the mycobiota as an entry point to explore the mechanism of action of Paeonol against ALD. Here, we found that Paeonol is effective against ALD inflammatory lesions and relieves liver fat lesions. Furthermore, we found that after the treatment of Paeonol, the fungal dysbiosis is improved, and the fungal abundance is reduced, and the translocation of beta-glucan to the liver and its mediated Dectin-1/IL-1 beta signaling pathway is blocked. Our study shows that paeonol ameliorated acute ALD-related inflammatory injury to the liver by alleviating intestinal fungal dysbiosis and inhibiting the mycobiota-mediated Dectin-1/IL-1 beta signaling pathway.