Structure--activity relationship of fluorine-containing renin inhibitory peptides based upon the tertiary structure of human renin.
Structure--activity relationship of fluorine-containing renin inhibitory peptides based upon the tertiary structure of human renin.
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基于人肾素三级结构的含氟肾素抑制肽的构效关系。
DOI：
10.1248/cpb.36.3447
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发表时间：
1988
影响因子：
1.7
通讯作者：
H. Umeyama
中科院分区：
文献类型：
--
作者：
K. Akahane;T. Kamijo;K. Iizuka;T. Taguchi;Y. Kobayashi;Y. Kiso;H. Umeyama
基于人肾素的三级结构，讨论了酰基-组氨酸-三氟化亮氨醇衍生物作为人肾素抑制剂的构效关系，该三级结构是通过假设结构相似性从青霉蛋白酶的晶体结构推导出来的。讨论了抑制剂的结构要求以及肾素结合位点可能的相互作用。
The structure-activity relationship of acyl-His-trifluorinated leucinol derivatives as inhibitors of human renal renin is discussed based upon the tertiary structure of human renin, which was deduced from the crystal structure of penicillopepsin by assuming structural similarity. The structural requirements for the inhibitors and possible interactions at the renin binding site are discussed.