Deactivation of the limbic system during acute psychosocial stress: Evidence from positron emission tomography and functional magnetic resonance Imaging studies
Deactivation of the limbic system during acute psychosocial stress: Evidence from positron emission tomography and functional magnetic resonance Imaging studies
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DOI：
10.1016/j.biopsych.2007.04.041
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发表时间：
2008-01-15
影响因子：
10.6
通讯作者：
Lupien, Sonia
中科院分区：
文献类型：
--
作者：
Pruessner, Jens C.;Declovic, Katarina;Lupien, Sonia
背景：应激引起的代谢变化可能会对健康造成不利影响。新开发的研究神经成像环境中压力的范式允许评估与对压力的感知和代谢反应相关的大脑激活变化。方法：在一项正电子发射断层扫描(n=10)和一项功能磁共振成像(fMRI；n=40)实验中，我们将受试者暴露于心理社会应激源。结果：我们观察到对应激源做出反应的受试者边缘系统组件包括海马体、下丘脑、中眶前额皮质和前扣带皮质的深度失活，内分泌应激标记皮质醇显著增加。此外，在功能磁共振成像研究中，海马区的失活程度与应激任务中皮质醇的释放有关。结论：观察到的边缘系统结构的失活表明在静息和非应激情况下激活程度升高。提出了一个模型，其中观察到的边缘系统活动的减少对于启动应激反应是必不可少的。
Background: Stress-induced metabolic changes can have detrimental health effects. Newly developed paradigms to investigate stress in neuroimaging environments allow the assessment of brain activation changes in association with the perception of and the metabolic response to stress.Methods: We exposed human subjects to a psychosocial stressor in one positron emission tomography (n = 10) and one functional magnetic resonance imaging (fMRI; n = 40) experiment.Results: We observed a profound deactivation of limbic system components including hippocampus, hypothalamus, medio-orbitofrontal cortex and anterior cingulate cortex in subjects who reacted to the stressor with a significant increase of the endocrine stress marker cortisol. Further, in the fMRI study, the degree of deactivation in the hippocampus was correlated with the release of cortisol in response to the stress task.Conclusions: The observed deactivation of limbic system structures suggests elevated activation at rest and during nonstressful situations. A model is proposed where the observed reduction in limbic system activity is essential for the initiation of the stress response.