Influence of Helicobacter pylori infection on the prevalence and patterns of upper gastrointestinal symptoms in Nigerians with diabetes mellitus
Influence of Helicobacter pylori infection on the prevalence and patterns of upper gastrointestinal symptoms in Nigerians with diabetes mellitus
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幽门螺杆菌感染对尼日利亚糖尿病患者上消化道症状患病率和模式的影响
DOI：
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发表时间：
2017
影响因子：
0.9
通讯作者：
O. Fasanmade
中科院分区：
文献类型：
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作者：
A. Oluyemi;E. Anomneze;Stella I Smith;O. Fasanmade
背景：幽门螺杆菌感染在我们的环境中广泛存在。然而，这一事实是否有任何关系的患病率和模式的症状，可与上消化道（GI）系统在我们的人口糖尿病（DM）患者还没有太多的研究。目的：我们开始这项研究，以评估如果H。pylori感染在尼日利亚的拉各斯的2型糖尿病患者的上消化道症状的患病率和模式中起重要作用。材料与方法：采用病例对照设计。从拉各斯大学教学医院招募了100名连续的、自愿的、非卧床的2型糖尿病患者，并从同一医院的门诊部抽取了100名年龄和性别匹配的非糖尿病对照者。对所有受试者进行了活动性H. pylori感染，进行人体测量，并完成结构化问卷调查，以在研究前3个月内引出各种上GI症状的存在。进一步检测对照组的DM。分析时，将症状分为消化不良、胃食管反流（格尔）和其他。结果：H. pylori感染与消化不良无显著相关性（χ2 [1] = 2.198，P = 0.138），与格尔症状提示无显著相关性（χ2 [1] = 3.742，P = 0.053）。此外，病例组和对照组的其他上消化道症状也相同（χ2 [1] = 0.157，P = 0.203）。H. pylori感染在DM组和对照组分别为18%和13%，但差异无统计学意义（χ2 [1] = 0.954，P = 0.329）。结论：H.根据本研究的结果，幽门螺杆菌似乎不会影响尼日利亚DM患者上消化道症状的患病率和模式。
Background: Infection with Helicobacter pylori infection is widespread in our environment. However, whether this fact has any bearing on the prevalence and pattern of symptoms referable to the upper gastrointestinal (GI) system in our population of diabetes mellitus (DM) patients has not been much studied. Aim: We embarked on this study to evaluate if H. pylori infection played any significant role in the prevalence and patterns of upper GI symptoms in type 2 DM patients in Lagos, Nigeria. Materials and Methods: A case–control design was employed. One hundred consecutive, consenting, and ambulant type 2 DM patients were recruited from the Lagos University Teaching Hospital and 100 age- and sex-matched nondiabetic controls were drawn from medical outpatient clinics of the same hospital. All subjects were investigated for a marker of active infection with H. pylori via stool antigen testing, had anthropometric measurements taken, and completed a structured questionnaire administered to elicit for the presence of various upper GI symptoms over the preceding 3 months prior to the time of the study. The controls were further tested for DM. For analysis, the symptoms were divided into dyspepsia, gastroesophageal reflux (GER), and others. Results: H. pylori infection status was neither significantly associated with dyspepsia in either cases or controls (χ2 [1] = 2.198, P = 0.138) nor significantly associated with the symptomatic suggestion of GER in either cases or controls (χ2 [1] = 3.742, P = 0.053). Moreover, the same held for the other upper GI symptoms in cases or controls (χ2 [1] = 0.157, P = 0.203). H. pylori infection was detected in 18% of DM patients and 13% of controls, but there was no statistical significance in this difference (χ2 [1] = 0.954, P = 0.329). Conclusion: Infection with H. pylori does not appear, from the results of this study, to influence the prevalence and patterns of upper GI symptoms in patients with DM in Nigeria.