Accuracy of FDG-PET-CT in the Diagnostic Work-up of Vascular Prosthetic Graft Infection
Accuracy of FDG-PET-CT in the Diagnostic Work-up of Vascular Prosthetic Graft Infection
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DOI：
10.1016/j.ejvs.2010.05.016
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发表时间：
2010-09-01
影响因子：
5.7
通讯作者：
Zeebregts, C. J.
中科院分区：
文献类型：
--
作者：
Bruggink, J. L. M.;Glaudemans, A. W. J. M.;Zeebregts, C. J.
目的：探讨氟-2-脱氧-D-葡萄糖正电子发射断层扫描（FDG-PET）与计算机断层扫描（CT）扫描相比的诊断准确性以及融合FDG-PET CT在诊断人工血管感染中的附加值。设计：回顾性分析的前瞻性队列研究。材料：25例临床疑似人工血管感染的患者接受了CT和FDG-PET扫描。方法：两名核医学医师评估了 FDG-PET 扫描；所有 CT 扫描均由两名放射科医生进行评估。融合FDG-PET/CT由放射科医生和核医学医师进行判断。研究了 CT 和 FDG-PET 之间的一致性以及不同读者之间观察者间的一致性。结果：15 名患者经培养证实感染。单一 FDG-PET 的结果最好（敏感性 93%，特异性 70%，阳性预测值 82%，阴性预测值 88%）。对于 CT，这些值分别为 56%、57%、60% 和 58%。融合CT和FDG-PET成像也显示出高敏感性和特异性率以及高阳性和阴性值。 FDG-PET 分析的观察者间一致性非常好（kappa = 1.00），CT 和融合 FDG-PET CT 分析的观察者间一致性中等（分别为 0.63 和 0.66）。结论：在检测血管假体感染方面，FDG-PET 扫描显示出比 CT 更好的诊断准确性。这项研究表明，FDG-PET 为诊断血管假体移植物感染的检查提供了有用的工具。 (C) 2010 年欧洲血管外科学会。由爱思唯尔有限公司出版。保留所有权利。
Objectives: To investigate the diagnostic accuracy of fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) compared with computed tomography (CT) scanning and added value of fused FDG-PET CT in diagnosing vascular prosthetic graft infection.Design: Prospective cohort study with retrospective analysis.Materials: Twenty five patients with clinically suspected vascular prosthetic infection underwent CT and FDG-PET scanning.Methods: Two nuclear medicine physicians assessed the FDG-PET scans; all CT scans were assessed by two radiologists. Fused FDG-PET/CT were judged by the radiologist and the nuclear medicine physician. The concordance between CT and FDG-PET and the inter-observer agreement between the different readers were investigated.Results: Fifteen patients had a proven infection by culture. Single FDG-PET had the best results (sensitivity 93%, specificity 70%, positive predictive value 82% and negative predictive value 88%). For CT, these values were 56%, 57%, 60% and 58%, respectively. Fused CT and FDG-PET imaging also showed high sensitivity and specificity rates and high positive and negative values. Inter-observer agreement for FDG-PET analysis was excellent (kappa = 1.00) and moderate for CT and fused FDG-PET CT analysis (0.63 and 0.66, respectively).Conclusion: FDG-PET scanning showed a better diagnostic accuracy than CT for the detection of vascular prosthetic infection. This study suggests that FDG-PET provides a useful tool in the work-up for diagnosis of vascular prosthetic graft infection. (C) 2010 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.