Dynamic Control of Response Criterion in Premotor Cortex during Perceptual Detection under Temporal Uncertainty
Dynamic Control of Response Criterion in Premotor Cortex during Perceptual Detection under Temporal Uncertainty
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DOI：
10.1016/j.neuron.2015.04.014
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发表时间：
2015-05-20
期刊：
影响因子：
16.2
通讯作者：
Parga, Nestor
中科院分区：
文献类型：
--
作者：
Carnevale, Federico;de Lafuente, Victor;Parga, Nestor
在不确定的情况下，大脑使用先前的知识将感官输入转换为决策所依据的感知。然而，当不确定性在于感觉证据的时间时，使用先前获得的时间信息的机制仍然未知。我们研究这个问题在猴子执行检测任务与可变的刺激时间。我们使用假警报的神经相关性来推断受试者的反应标准，并发现它在试验过程中进行调节。前运动皮层活动的分析表明，这种调制是由人口的动态反应。一个经过训练的递归网络模型再现了实验结果，并展示了一种神经机制，可以从感知检测中的时间期望中受益。关于刺激随时间的概率的先前知识可以内在地编码在神经群体动力学中，从而允许随时间灵活地控制响应标准。
Under uncertainty, the brain uses previous knowledge to transform sensory inputs into the percepts on which decisions are based. When the uncertainty lies in the timing of sensory evidence, however, the mechanism underlying the use of previously acquired temporal information remains unknown. We study this issue in monkeys performing a detection task with variable stimulation times. We use the neural correlates of false alarms to infer the subject's response criterion and find that it modulates over the course of a trial. Analysis of premotor cortex activity shows that this modulation is represented by the dynamics of population responses. A trained recurrent network model reproduces the experimental findings and demonstrates a neural mechanism to benefit from temporal expectations in perceptual detection. Previous knowledge about the probability of stimulation over time can be intrinsically encoded in the neural population dynamics, allowing a flexible control of the response criterion over time.