The seroprevalence and seroincidence of enterovirus71 infection in infants and children in Ho Chi Minh City, Viet Nam.
The seroprevalence and seroincidence of enterovirus71 infection in infants and children in Ho Chi Minh City, Viet Nam.
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DOI：
10.1371/journal.pone.0021116
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发表时间：
2011-01-01
期刊：
影响因子：
3.7
通讯作者：
Simmons, Cameron P
中科院分区：
文献类型：
--
作者：
Tran, Chau Bich Nguyen;Nguyen, Hieu Trong;Simmons, Cameron P
在过去十年中，与肠病毒71 （EV71）相关的手足口病已成为东南亚的一个严重公共卫生问题。为了更好地了解EV71感染的流行情况，我们在越南胡志明市的健康婴儿和儿童中测定了EV71的血清患病率和血清发病率。在一组200名新生儿中，55%的脐带血样本含有EV71中和抗体，98%的婴儿在6个月大时这些抗体衰减到无法检测到的水平。出生第一年EV71中和抗体血清转化率为5.6%，出生第二年为14%。在5-15岁的儿童中，EV71中和抗体的血清阳性率为84%，脐带血阳性率为55%。综上所述，这些数据表明EV71型病毒的感染力很高，并突出表明需要在高疾病负担国家对其流行病学和发病机制进行更多研究。
Enterovirus 71 (EV71)-associated hand, foot and mouth disease has emerged as a serious public health problem in South East Asia over the last decade. To better understand the prevalence of EV71 infection, we determined EV71 seroprevalence and seroincidence amongst healthy infants and children in Ho Chi Minh City, Viet Nam. In a cohort of 200 newborns, 55% of cord blood samples contained EV71 neutralizing antibodies and these decayed to undetectable levels by 6 months of age in 98% of infants. The EV71 neutralizing antibody seroconversion rate was 5.6% in the first year and 14% in the second year of life. In children 5-15 yrs of age, seroprevalence of EV71 neutralizing antibodies was 84% and in cord blood it was 55%. Taken together, these data suggest EV71 force of infection is high and highlights the need for more research into its epidemiology and pathogenesis in high disease burden countries.