Apnea-hypopnea and desaturations in heart failure with reduced ejection fraction: Are we aiming at the right target?
Apnea-hypopnea and desaturations in heart failure with reduced ejection fraction: Are we aiming at the right target?
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DOI：
10.1016/j.ijcard.2015.11.108
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发表时间：
2016-01-15
影响因子：
3.5
通讯作者：
Damy, Thibaud
中科院分区：
文献类型：
--
作者：
Gellen, Barnabas;Canoui-Poitrine, Florence;Damy, Thibaud
背景：睡眠呼吸障碍(SDB)在心力衰竭射血分数(HFrEF)降低的患者中很常见。呼吸暂停低通气指数(AHI)升高与预后不良有关。方法：连续376例慢性心功能衰竭患者，平均年龄59±13岁，平均左心室射血分数30+/-6%，平均呼吸暂停低通气指数18[IQR9.33]。死亡、心脏移植或左心室辅助治疗的综合终点98例(26%)发生在3年内。睡眠中的最低血氧饱和度(MOS)，减饱和度的次数
Background: Sleep disordered breathing (SDB) is common in patients with heart failure with reduced ejection fraction (HFrEF). An increased apnea-hypopnea index (AHI) is associated with poor outcomes. We examined whether an analysis of nocturnal desaturations (NDs) can improve the risk stratification.Methods: Three-hundred seventy-six consecutive patients with stable chronic HFrEF and LVEF = 15. The mean age was 59 +/- 13 years, the mean LVEF was 30 +/- 6%, and the median AHI was 18 [IQR: 9.33). The composite end-point of death, heart transplantation or LV assistance occurred in 98 patients (26%) within 3 years. Minimal oxygen saturation (MOS) during sleep, the number of desaturations