Passerini multicomponent reaction of protected α-aminoaldehydes as a tool for combinatorial synthesis of enzyme inhibitors
Passerini multicomponent reaction of protected α-aminoaldehydes as a tool for combinatorial synthesis of enzyme inhibitors
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DOI：
10.1039/b002027n
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发表时间：
2000-01-01
影响因子：
4.9
通讯作者：
Riva, R
中科院分区：
文献类型：
--
作者：
Banfi, L;Guanti, G;Riva, R
N-Boc-α-氨基醛与各种异氰化物和羧酸的三组分Passerini缩合在Boc-脱保护/转酰化之后导致含有α-羟基-β-氨基酸单元或在氧化之后含有α-氧代-β-氨基酸单元的复杂肽样结构。
Three-component Passerini condensation of N-Boc-alpha-aminoaldehydes with various isocyanides and carboxylic acids leads, after Boc-deprotection/transacylation, to complex peptide-like structures containing an alpha-hydroxy-beta-aminoacid unit or, after oxidation, an alpha-oxo-beta-aminoacid unit.