Fifteen-year study of the changing epidemiology of methicillin-resistant Staphylococcus aureus
Fifteen-year study of the changing epidemiology of methicillin-resistant Staphylococcus aureus
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DOI：
10.1016/j.amjmed.2006.01.004
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发表时间：
2006-11-01
影响因子：
5.9
通讯作者：
Russell, Kevin L.
中科院分区：
文献类型：
--
作者：
Crum, Nancy F.;Lee, Rachel U.;Russell, Kevin L.
目得：该研究的目的是阐明耐甲氧西林金黄色葡萄球菌（MRSA）infections.METHODS：MRSA的进化，微生物学和临床特征，从1990年至2004年在圣地亚哥的军事医疗设施，进行了评估和分类为社区获得性或医院。序列类型，葡萄球菌染色体盒基因型，和潘顿-瓦伦丁杀白细胞素基因状态的一个子集的分离株。结果：在15年期间，1888例MRSA被确定，65%的社区获得。发病率（2004年为155例/10万人年）和家庭相关病例自2002年以来迅速增加。在社区获得性MRSA患者中，16%住院治疗，只有17%最初给予有效的抗生素。社区获得性MRSA病例与医院获得性MRSA病例相比，更常见于软组织感染，而较少发生于泌尿系统、肺部或血流感染（P
PURPOSE: The study's purpose was to elucidate the evolutionary, microbiologic, and clinical characteristics of methicillin-resistant Staphylococcus aureus ( MRSA) infections.METHODS: MRSA cases from military medical facilities in San Diego, from 1990 to 2004, were evaluated and categorized as community- acquired or nosocomial. Sequence type, staphylococcal chromosomal cassette gene type, and Panton- Valentine leukocidin gene status were determined for a subset of isolates.RESULTS: Over the 15- year period, 1888 cases of MRSA were identified; 65% were community acquired. The incidence ( 155 infections/ 100 000 person- year in 2004) and household- associated cases rapidly increased since 2002. Among persons with community- acquired MRSA, 16% were hospitalized and only 17% were initially given an effective antibiotic. Community- acquired MRSA cases compared with nosocomial MRSA cases were more often soft- tissue and less often urinary, lung, or bloodstream infections ( P