Association between female breast cancer and cutaneous melanoma
Association between female breast cancer and cutaneous melanoma
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DOI：
10.1002/ijc.20322
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发表时间：
2004-09-20
影响因子：
6.4
通讯作者：
Tsao, H
中科院分区：
文献类型：
--
作者：
Goggins, W;Gao, W;Tsao, H
流行病学研究已经提供了皮肤黑色素瘤(CM)和乳腺癌(BC)之间联系的提示性证据。此外，乳腺癌易感基因BRCA2突变的携带者患黑色素瘤的风险增加，而黑色素瘤易感基因CDKN2A突变的携带者患乳腺癌的风险高于预期。这些发现提出了一种可能性，即参与CM和BC发展的途径是重叠的，其中一种癌症的幸存者可能倾向于发展另一种癌症。为此，我们开始确定监测、流行病学和最终结果(SEER)数据库中的女性BC幸存者是否有更高的CM风险，反之亦然。我们跟踪了登记在19731999 SEER数据库中的女性BC患者以发展第二个CM，并跟踪女性CM患者发展第二个BC。然后使用标准化发病率将预期病例数与观察到的病例数进行比较。总体而言，我们发现，在BC女性幸存者中，CM的风险略有增加，但在统计学上有显著意义，反之亦然。在年轻的BC患者中，我们观察到第二次CM的风险增加了46%。接受放射治疗的女性患CM的风险增加了42%。女性CM幸存者患BC的风险和BC幸存者患CM的风险也增加了，尽管程度要小得多(总体来说，分别为11%和16%)。我们发现女性BC和CM之间存在相互关联。CM的风险升高，特别是在年轻的BC患者中，表明来自高危人群的遗传观察也可能在普通BC人群中以低得多的水平进行操作。(C)2004年Wiley-Liss公司
Epidemiologic studies have provided suggestive evidence of a link between cutaneous melanoma (CM) and breast cancer (BC). Moreover, carriers of mutations in the breast cancer predisposition gene, BRCA2, have an increased risk of melanoma while carriers of mutations in the melanoma sus- ceptibility gene, CDKN2A, exhibit a higher than expected risk of breast cancer. These findings raise the possibility that pathways involved in the development of CM and BC overlap and that survivors of one cancer may be prone to develop the other. To this end, we set out to determine if survivors of female BC in the Surveillance, Epidemiology and End Result (SEER) database are at increased risk for CM and vice versa. We followed female BC patients registered in the 19731999 SEER database for development of a second CM and female CM patients for the development of a second BC. The expected number of cases was then compared to the observed number of cases using standardized incidence ratios. Overall, we found a modest but statistically significant increased risk of CM among female BC survivors and vice versa. Among young BC patients, we observed a 46% elevated risk of a second CM. Women who underwent radiation therapy exhibited a 42% increased risk for CM. The risks of BC among female CM survivors and CM among BC survivors were also elevated, albeit to a much lesser degree (overall, 11% and 16%, respectively). We found a mutual association between female BC and CM. The elevated risk for CM, especially among younger BC patients, suggests that the genetic observations from high-risk groups may also be operative at a much lower level in the general BC population. (C) 2004 Wiley-Liss, Inc.