Pre-Existing HCV Variants Resistant to DAAs and Their Sensitivity to PegIFN/RBV in Chinese HCV Genotype 1b Patients.
Pre-Existing HCV Variants Resistant to DAAs and Their Sensitivity to PegIFN/RBV in Chinese HCV Genotype 1b Patients.
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中国 HCV 基因型 1b 患者中已有的 DAA 耐药性 HCV 变异及其对 PegIFN/RBV 的敏感性
DOI：
10.1371/journal.pone.0165658
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Xu X
中科院分区：
文献类型：
--
作者：
Zhang Y;Cao Y;Zhang R;Zhang X;Lu H;Wu C;Huo N;Xu X
Background The efficacy of direct-acting antiviral agents (DAAs) could be attenuated by the presence of resistance-associated variants (RAVs). The aim of this study was to investigate the natural prevalence of RAVs among Chinese HCV genotype 1b patients and analyze the efficacy of pegylated interferon (PegIFN)/ribavirin (RBV) therapy in patients with and without RAVs at baseline. Methods Direct sequencing of the HCV NS3, NS5A and NS5B regions was performed in baseline serum samples of 117 DAAs-naïve subjects infected with HCV genotype 1b. The efficacy of PegIFN/RBV therapy in patients with and without RAVs at baseline was analyzed by comparing the response rates between patients with RAVs and patients with wild type virus. Results The incidence of RAVs was 8.00% (8/100) in the NS3 region (T54S, n = 1, 1.00%; R117H, n = 5, 5.00%; S122T, n = 1, 1.00%; S174F, n = 1, 1.00%), 29.91% (32/107) in the NS5A region (L28M, n = 12, 11.21%; R30Q, n = 10, 9.35%; L31M, n = 1, 0.93%; P58S, n = 4, 3.74%; Y93H, n = 8, 7.48%) and 98.15% (106/108) in the NS5B region (L159F, n = 1, 0.93%; C316N, n = 103, 95.37%; A421V, n = 6, 5.56%). The response rates to PegIFN/RBV treatment did not differ between patients with or without RAVs in the NS5A region. Conclusions Pre-existing RAVs, including key RAVs, were detected in Chinese DAAs-naïve patients infected with HCV genotype 1b. IFN-based therapy could be a good option for patients with RAVs, especially key RAVs, at baseline.
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影响因子：
4.8
作者：
Paolucci S;Fiorina L;Mariani B;Gulminetti R;Novati S;Barbarini G;Bruno R;Baldanti F
通讯作者：
Baldanti F
影响因子：
5.2
作者：
Peres-da-Silva, Allan;de Almeida, Adilson Jose;Lampe, Elisabeth
通讯作者：
Lampe, Elisabeth
影响因子：
4.9
作者：
Fridell, Robert A.;Qiu, Dike;Gao, Min
通讯作者：
Gao, Min
影响因子：
12.7
作者：
Larousse, Jameleddine Aissa;Trimoulet, Pascale;Fleury, Herve
通讯作者：
Fleury, Herve
影响因子：
6.1
作者：
Wang Li;Du Fan;Zhao Shi
通讯作者：
Zhao Shi