Comparison of the growth hormone, IGF-1 and insulin in cerebrospinal fluid and serum between patients with motor neuron disease and healthy controls
Comparison of the growth hormone, IGF-1 and insulin in cerebrospinal fluid and serum between patients with motor neuron disease and healthy controls
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DOI：
10.1111/j.1468-1331.2006.01503.x
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发表时间：
2006-12-01
影响因子：
5.1
通讯作者：
Zagar, M.
中科院分区：
文献类型：
--
作者：
Bilic, E.;Bilic, E.;Zagar, M.
生长激素（GH）、胰岛素样生长因子-1（IGF-1）和胰岛素对中枢神经系统的神经营养作用在过去十年中变得更加明显。在这项研究中，我们测定了35例运动神经元病（MND）患者[24例确诊肌萎缩侧索硬化（ALS）患者和11例进行性球麻痹患者]和40名健康对照者血清和脑脊液（CSF）中GH、IGF-1和胰岛素的浓度。MND患者组血清GH和IGF-1水平与健康对照组无显著差异，而胰岛素水平在MND患者组中显著降低（P = 0.0033）。MND组CSF中IGF-1和胰岛素水平均显著低于健康对照组，差异有统计学意义（P < 0.001）。这一发现以前没有报道过，进一步研究它与ALS的关系应该确定它是否可以作为疾病的早期标志物，或者它是否仅仅代表ALS发展的结果。
Neurotrophic effects of the growth hormone (GH), insulin-like growth factor-1 (IGF-1) and insulin on the central nervous system have become more apparent in the past decade. In this study, we measured serum and cerebrospinal fluid (CSF) concentrations of GH, IGF-1 and insulin in 35 patients with motor neuron disease (MND) [24 patients with definite amyotrophic lateral sclerosis (ALS) and 11 patients with progressive bulbar palsy] and in 40 healthy controls. Levels of serum concentrations of GH and IGF-1 did not significantly differ between the MND patient group and the healthy controls, while the level of insulin was significantly decreased (P = 0.0033) in the MND patient group. However, levels of all three examined parameters in CSF were significantly lower in the MND group than in the healthy controls with the statistical significance for IGF-1 and insulin of P < 0.001. This finding has not been reported previously, and further investigations into its association with ALS should establish whether it can be used as an early marker of the disease, or whether it merely represents a consequence of ALS development.