Sildenafil Increases Uterine Blood Flow in Nonpregnant Nulliparous Women
Sildenafil Increases Uterine Blood Flow in Nonpregnant Nulliparous Women
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DOI：
10.1177/1933719109354648
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发表时间：
2010-04-01
影响因子：
2.9
通讯作者：
Bernstein, Ira M.
中科院分区：
文献类型：
--
作者：
Hale, Sarah A.;Jones, Cresta W.;Bernstein, Ira M.
本研究探讨了西地那非对未怀孕、未生育妇女子宫容量血流量（UVF）和血管阻抗的影响。15名妇女在月经周期的黄体期随机接受安慰剂或西地那非（25或100毫克）。分别于给药后1小时和3小时对双侧子宫动脉进行彩色多普勒超声检查，计算阻力指数（RI）和UVF。在3小时的监测期间，接受西地那非的患者UVF显著增加，RI显著降低。当对西地那非的UVF反应作为基线UVF的函数进行检查时，仅在基线UVF较高的参与者中观察到UVF的显着增加。总的来说，处于黄体期的女性对西地那非的反应显示出UVF的显著增加。然而，这种增加似乎与基础UVF直接相关。
This study investigated the effect of sildenafil on uterine volumetric blood flow (UVF) and vascular impedance in nonpregnant, nulliparous women. Fifteen women were randomized in a double-blind fashion to receive either placebo or sildenafil (25 or 100 mg) during the luteal phase of the menstrual cycle. Color Doppler ultrasound of both uterine arteries was performed at baseline and at 1 and 3 hours postdosing to calculate resistance index ( RI) and UVF. Those who received sildenafil significantly increased UVF and decreased RI over the 3-hour monitoring period. When UVF responses to sildenafil were examined as a function of baseline UVF, a significant increase in UVF was observed in only those participants with higher baseline UVF. Overall, women in the luteal phase demonstrated a significant increase in UVF in response to sildenafil. However, this increase appears to be directly associated with basal UVF.