Olfactory and gustatory abnormalities in COVID-19 cases
Olfactory and gustatory abnormalities in COVID-19 cases
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DOI：
10.1007/s00405-020-06155-9
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发表时间：
2020-06-23
影响因子：
2.6
通讯作者：
Bal, Cengiz
中科院分区：
文献类型：
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作者：
Altin, Fazilet;Cingi, Cemal;Bal, Cengiz
在撰写本文时，一场流行病几乎影响到地球上每一个国家。临床医生和非专业人士对COVID-19患者的嗅觉缺失和老年痴呆进行了大量讨论。我们的目的是报道一系列住院病人的嗅觉和味觉综合测试结果。方法对81例新型冠状病毒肺炎（COVID-19）感染者进行前瞻性研究，检测结果均为2019 n-cov实时荧光定量PCR。对照组由40名COVID-19阴性患者组成。嗅觉和味觉测试由审查员使用严格的安全标准并穿着全套个人防护装备进行。然后将病例组获得的结果与对照组获得的结果进行比较。结果病例组中男性41例（50.6%），女性40例（49.4%），平均年龄54.16±16.98岁（18-95岁）。对照组男性21例（52.5%），女性19例（47.5%），平均年龄55±15.39岁（18-90岁）。50例（61.7%）covid -19阳性患者有与嗅觉相关的投诉。病例组嗅觉症状分布与对照组差异有统计学意义（p < 0.001）。至于味觉异常，在病例组中，22人（27.2%）有味觉功能障碍。病例与对照组味觉异常分布差异有统计学意义（p < 0.001）。结论嗅觉和味觉功能障碍与SARS-CoV-2感染密切相关。伴有或不伴有缺氧的低氧血症可能是潜伏性COVID-19的可靠指标。
Purpose At the time of writing, there is a pandemic affecting virtually every country on Earth. There is considerable discussion amongst clinicians as well as lay people about anosmia and ageusia in COVID-19 sufferers. We aimed to report the results from comprehensive olfactory and gustatory testing in a series of hospital in-patients. Methods The prospective study evaluated 81 individuals with a COVID-19 infection, as confirmed by 2019 n-cov Real-Time PCR laboratory testing. The control group consisted of forty individuals with COVID-19 negative. Olfactory and gustatory testings were carried out by an examiner utilizing stringent safety standards and wearing full personal protective equipment. The results obtained in the case group were then compared with those obtained for the controls. Results In the case group, 41(50.6%) of patients were male and 40 (49.4%) were female, mean age of 54.16 +/- 16.98 years (18-95). In the control group, 21 (52.5%) of subjects were male and 19 (47.5%) were female, and mean age was 55 +/- 15.39 years (18-90). Fifty (61.7%) COVID-19-positive patients had complaints related to olfaction. The distribution of olfactory symptoms in the case group differed at the level of statistical significance from the control group (p < 0.001). Turning to gustatory abnormalities, within the case group, 22 individuals (27.2%) had taste malfunction. A statistically significant difference was found in the distribution of gustatory abnormalities between cases and controls (p < 0.001). Conclusions Olfactory and gustatory dysfunctions are strongly associated with SARS-CoV-2 infection. Hyposmia with or without hypogeusia is potentially a reliable indicator of latent COVID-19.