Influence of recent exercise and skin temperature on ultrasound Doppler measurements in patients with rheumatoid arthritis-an intervention study
Influence of recent exercise and skin temperature on ultrasound Doppler measurements in patients with rheumatoid arthritis-an intervention study
复制标题
DOI：
10.1093/rheumatology/kep294
复制
发表时间：
2009-12-01
期刊：
影响因子：
5.5
通讯作者：
Bliddal, Henning
中科院分区：
文献类型：
--
作者：
Ellegaard, Karen;Torp-Pedersen, Soren;Bliddal, Henning
Objective.超声多普勒（USD）在类风湿关节炎患者的诊断和治疗监测中的应用已大大增加。充血是炎症反应的组成部分，因此，发炎滑膜中USD活性的量可用于量化炎症活性。目前尚不清楚，但是，是否充血单独反映了疾病的活动性或可能受到其他因素的影响。29例RA患者在三次干预之前和之后立即进行了手腕USD检查。干预行动分三天进行。干预措施包括（i）手部和前臂肌肉的等长运动，（ii）手部加热和（iii）手部冷却。通过测量滑膜中颜色的百分比-颜色分数（CF）来量化腕关节中的多普勒量。比较每次干预前后的CF估计值，以观察是否有干预影响了滑膜中的多普勒量。手冷却后CF显著降低（P=0.018，
Objective. Use of ultrasound Doppler (USD) in diagnosing and treatment monitoring of patients with RA has increased considerably. Hyperaemia is an integral part of the inflammatory response, and the amount of USD activity in an inflamed synovium may therefore be used to quantify the inflammatory activity. It is unclear, however, whether the hyperaemia alone reflects the disease activity or may be influenced by other factors.Methods. Twenty-nine patients with RA underwent USD examination of the wrist before and immediately after three interventions. The interventions were carried out on three separate days. The interventions were (i) isometric exercise of the muscles of the hand and forearm, (ii) heating and (iii) cooling of the hand. The amount of Doppler in the wrist joint was quantified by measuring the percentage of colour in the synovium-the colour fraction (CF). The CF values estimated before and after each intervention were compared to see if any intervention affected the amount of Doppler in the synovium.Results. The CF decreased significantly after cooling of the hand (P=0.018 and