Factors affecting graft survival after liver transplantation from donation after cardiac death donors
Factors affecting graft survival after liver transplantation from donation after cardiac death donors
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DOI：
10.1097/01.tp.0000250936.73034.98
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发表时间：
2006-12-27
期刊：
影响因子：
6.2
通讯作者：
Maley, Warren R.
中科院分区：
文献类型：
--
作者：
Lee, Kwang-Woong;Simpkins, Christopher E.;Maley, Warren R.
Background. Liver transplantation from donation after cardiac death (DCD) donors is an increasingly common approach for expansion of the donor organ supply. However, transplantation with DCD livers results in inferior graft survival. In this study, we examined donor and recipient characteristics that are associated with poor allograft outcomes and present a set of criteria that permit allograft survival that is comparable to that of donation after brain death (DBD) grafts in both low- and high-risk recipients.Methods. The United Network for Organ Sharing/Organ Procurement and Transplantation Network Liver Transplantation Registry between January 1996 and March 2006 was investigated. Adult DCD liver transplants (n=874) were included.Results. A DCD risk index was developed using the statistically significant factors from a multivariate Cox model: history of previous transplantation, life support status at transplantation, donor age, donor warm ischemia time (DWIT), and cold ischemia time (CIT). Favorable DCD donor criteria were donor age
