Red blood cell distribution width is a potential index to assess the disease activity of systemic lupus erythematosus
Red blood cell distribution width is a potential index to assess the disease activity of systemic lupus erythematosus
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红细胞分布宽度是评估系统性红斑狼疮疾病活动性的潜在指标
DOI：
10.1016/j.cca.2013.08.007
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发表时间：
2013-10-21
影响因子：
5
通讯作者：
Deng, An-Mei
中科院分区：
文献类型：
--
作者：
Hu, Zhi-De;Chen, Yan;Deng, An-Mei
背景资料：基于人群的调查显示，红细胞分布宽度（RDW）与炎症指标如红细胞沉降率（ESR）和C反应蛋白（CRP）相关。慢性炎症是许多自身免疫性疾病的主要组成部分之一，RDW也可以反映这些自身免疫性疾病的严重程度。因此，本研究旨在探讨RDW与系统性红斑狼疮（SLE）疾病活动性的相关性。分析RDW与疾病活动性及其他炎症指标的相关性。对3例初发SLE患者应用糖皮质激素治疗3个月，观察其对RDW的影响。RDW与血清IgM、CRP、ESR、SLE疾病活动指数2000（SLEDAI-2K）呈正相关。糖皮质激素治疗降低了SLEDAI-2K和RDW。结论：RDW可作为判断SLE病情活动性的一个有用指标。(C)2013爱思唯尔有限公司版权所有。
Background: General population-based investigations have revealed that red blood cell distribution width (RDW) is associated with inflammatory indexes such as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). Chronic inflammation is one of the major components of many autoimmune diseases and RDW may reflect the severity of these autoimmune diseases as well. Therefore, the objective of this study was to investigate the correlation between RDW and disease activity of systemic lupus erythematosus (SLE).Methods: The medical records of 131 SLE patients were retrospectively analyzed. Correlations between RDW and disease activity or other inflammatory indexes were analyzed. The effect of glucocorticoid treatment for three months on RDW was estimated in 3 newly diagnosed SLE cases.Results: Increased RDW was observed in SLE patients. RDW was positively correlated with serum IgM, CRP, ESR, and SLE Disease Activity Index 2000 (SLEDAI-2K). Glucocorticoid treatment decreased both SLEDAI-2K and RDW. Conclusion: RDW may be a useful index to estimate the disease activity of SLE. (C) 2013 Elsevier B.V. All rights reserved.