Differences in mood instability in patients with bipolar disorder type I and II: a smartphone-based study
Differences in mood instability in patients with bipolar disorder type I and II: a smartphone-based study
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DOI：
10.1186/s40345-019-0141-4
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发表时间：
2019-02-01
影响因子：
4
通讯作者：
Kessing, Lars Vedel
中科院分区：
文献类型：
--
作者：
Faurholt-Jepsen, Maria;Frost, Mads;Kessing, Lars Vedel
背景：双相情感障碍患者的情绪不稳定与复发风险相关。这项研究调查了I型和II型双相情感障碍患者情绪不稳定的差异，这在之前的研究中很少。方法I型（n=53）和II型（n=31）双相情感障碍患者使用基于智能手机的每日自我监测系统9个月。本研究的数据反映了15.975项每日收集的基于智能手机的患者情绪评估数据的观察结果。结果在调整了年龄、性别、病程和精神药物治疗的模型中，II型双相情感障碍患者在抑郁期间的情绪不稳定程度高于I型双相情感障碍患者（B值：0.27,95% CI 0.007; 0.53, p=0.044），但躁狂症状强度较低。与双相情感障碍I型患者相比，双相情感障碍II型患者并没有经历更低的平均情绪或更高强度的抑郁症状。结论与双相情感障碍I型相比，双相情感障碍II型患者有更高的抑郁情绪不稳定性。在临床上，识别这些发作间症状是很重要的。未来的研究调查治疗对情绪不稳定措施的影响是有必要的。试验注册编号NCT02221336
BackgroundMood instability in bipolar disorder is associated with a risk of relapse. This study investigated differences in mood instability between patients with bipolar disorder type I and type II, which previously has been sparingly investigated.MethodsPatients with bipolar disorder type I (n=53) and type II (n=31) used a daily smartphone-based self-monitoring system for 9months. Data in the present reflect 15.975 observations of daily collected smartphone-based data on patient-evaluated mood.ResultsIn models adjusted for age, gender, illness duration and psychopharmacological treatment, patients with bipolar disorder type II experienced more mood instability during depression compared with patients with bipolar disorder type I (B: 0.27, 95% CI 0.007; 0.53, p=0.044), but lower intensity of manic symptoms. Patients with bipolar disorder type II did not experience lower mean mood or higher intensity of depressive symptoms compared with patients with bipolar disorder type I.ConclusionsCompared to bipolar disorder type I, patients with bipolar disorder type II had higher mood instability for depression. Clinically it is of importance to identify these inter-episodic symptoms. Future studies investigating the effect of treatment on mood instability measures are warranted.Trial registration NCT02221336