GenBank
GenBank
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DOI：
10.1093/nar/25.1.1
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发表时间：
1997-01-01
影响因子：
14.9
通讯作者：
Ostell, J
中科院分区：
文献类型：
--
作者：
Benson, DA;Boguski, MS;Ostell, J
GenBank（R）是一个综合性数据库，包含380，000多个在属级或更低级别命名的生物体的公开核苷酸序列，主要通过单个实验室提交的数据和大规模测序项目（包括全基因组鸟枪测序（WGS）和环境采样项目）的批量提交数据获得。大多数提交是使用基于网络的BankIt或独立的Sequin程序进行的，登录号由GenBank工作人员在收到后分配。与欧洲核苷酸档案馆（ENA）和日本DNA数据库（DDBJ）的每日数据交换确保了全球范围的覆盖。基因库可通过NCBI检索系统访问，该系统整合了来自主要DNA和蛋白质序列数据库的数据，沿着分类学、基因组、作图、蛋白质结构和结构域信息，以及通过PubMed的生物医学期刊文献。BLAST提供GenBank和其他序列数据库的序列相似性检索。基因库数据库的完整双月发布和每日更新可通过FTP获得。要访问GenBank及其相关检索和分析服务，请从NCBI主页开始开始：GenBank序列数据库包括来自所有可用公共来源的DNA序列，主要是通过作者和大规模测序项目直接提交的序列数据，与EMBL数据库和日本DNA数据库的数据交换有助于确保全面覆盖，GenBank继续专注于质量控制和注释，同时扩大数据覆盖范围和检索服务，一个集成的检索系统，称为Zeroz，整合了来自主要DNA和蛋白质序列数据库的数据，沿着基因组图谱和蛋白质结构信息，还包括来自描述序列的已发表文章的MEDLINE摘要作为生物注释的附加来源。通过BLAST程序家族提供序列相似性搜索，NCBI的所有服务都是通过万维网提供的，此外，还有专门的服务器/客户端版本以及FTP和电子邮件管道访问。
GenBank (R) is a comprehensive database that contains publicly available nucleotide sequences for more than 380 000 organisms named at the genus level or lower, obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects, including whole genome shotgun (WGS) and environmental sampling projects. Most submissions are made using the web-based BankIt or standalone Sequin programs, and accession numbers are assigned by GenBank staff upon receipt. Daily data exchange with the European Nucleotide Archive (ENA) and the DNA Data Bank of Japan (DDBJ) ensures worldwide coverage. GenBank is accessible through the NCBI Entrez retrieval system that integrates data from the major DNA and protein sequence databases along with taxonomy, genome, mapping, protein structure and domain information, and the biomedical journal literature via PubMed. BLAST provides sequence similarity searches of GenBank and other sequence databases. Complete bimonthly releases and daily updates of the GenBank database are available by FTP. To access GenBank and its related retrieval and analysis services, begin at the NCBI Homepage: www.ncbi.nlm.nih.gov.The GenBank sequence database incorporates DNA sequences from all available public sources, primarily through the direct submission of sequence data from authors and from large-scale sequencing projects, Data exchange with the EMBL Data Library and the DNA Data Bank of Japan helps ensure comprehensive coverage, GenBank continues to focus on quality control and annotation while expanding data coverage and retrieval services, An integrated retrieval system, known as Entrez, incorporates data from the major DNA and protein sequence databases, along with genome maps and protein structure information, MEDLINE abstracts from published articles describing the sequences are also included as an additional source of biological annotation, Sequence similarity searching is offered through the BLAST family of programs, All of NCBI's services are offered through the World Wide Web, In addition, there are specialized server/client versions as well as FTP and e-mail sewer access.