Extending Nontargeted Discovery of Environmental Chemical Exposures during Pregnancy and Their Association with Pregnancy Complications-A Cross-Sectional Study.
Extending Nontargeted Discovery of Environmental Chemical Exposures during Pregnancy and Their Association with Pregnancy Complications-A Cross-Sectional Study.
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DOI：
10.1289/ehp11546
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发表时间：
2023-07
影响因子：
10.4
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中科院分区：
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非目标分析（NTA）方法识别新暴露；然而，很少有化学物质被量化并研究其与妊娠并发症的关系。我们表征了在之前的 NTA 步骤中鉴定、选择和确认的母体和脐带血中九种外源性和内源性化学物质的水平，包括直链和支链异构体全氟辛烷磺酸 (PFOS)、全氟己烷磺酸 (PFHxS)、邻苯二甲酸单乙基己酯、4-硝基苯酚、四乙二醇、十三烷二酸、十八烷二酸和脱氧胆酸。我们在旧金山的不同妊娠队列中评估了母体水平和脐带水平之间的关系以及妊娠期糖尿病 (GDM) 和妊娠期高血压疾病之间的关系。我们从旧金山“我们体内的化学物质”队列中的 302 名怀孕研究参与者收集了匹配的母体和脐带血清样本。通过 NTA 识别化学品并使用有针对性的方法进行量化。我们计算了分布和斯皮尔曼相关系数，测试母体和脐带血基质内和之间化学物质的关系。我们使用调整后的逻辑回归来计算与母体化学品暴露四分位数范围增加相关的 GDM 和妊娠期高血压疾病的几率。我们在至少 97% 的母体样本中检测到线性 PFOS、PFHxS、十八烷二酸和脱氧胆酸。相关性介于 0.9 和 0.9 之间。我们观察到脐带和母体的 PFHxS、线性 PFOS 和支链 PFOS 水平之间存在很强的相关性（分别为 0.8 和 0.8）。直链和支链 PFOS、十三烷二酸、十八烷二酸和脱氧胆酸的四分位距增加与 GDM 的比值比 (OR) 增加相关 [(95% CI: 0.89, 2.01)、1.24 (95% CI: 0.86, 1.80)、1.26 (95% CI: 0.93, 1.73)、分别为 1.24（95% CI：0.86、1.80）和 1.23（95% CI：0.87、1.75）]。十三烷二酸与妊娠期高血压呈正相关[(95% CI: 0.90, 1.86)]。我们确定了怀孕研究参与者中很少量化的外源性和内源性化学物质，这些化学物质也与妊娠并发症有关，并证明了 NTA 在识别值得关注的化学物质暴露方面的效用。 https://doi.org/10.1289/EHP11546
Nontargeted analysis (NTA) methods identify novel exposures; however, few chemicals have been quantified and interrogated with pregnancy complications. We characterized levels of nine exogenous and endogenous chemicals in maternal and cord blood identified, selected, and confirmed in prior NTA steps, including linear and branched isomers perfluorooctane sulfonate (PFOS), perfluorohexane sulfonate (PFHxS), monoethylhexyl phthalate, 4-nitrophenol, tetraethylene glycol, tridecanedioic acid, octadecanedioic acid, and deoxycholic acid. We evaluated relationships between maternal and cord levels and between gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy in a diverse pregnancy cohort in San Francisco. We collected matched maternal and cord serum samples at delivery from 302 pregnant study participants from the Chemicals in Our Bodies cohort in San Francisco. Chemicals were identified via NTA and quantified using targeted approaches. We calculated distributions and Spearman correlation coefficients testing the relationship of chemicals within and between the maternal and cord blood matrices. We used adjusted logistic regression to calculate the odds of GDM and hypertensive disorders of pregnancy associated with an interquartile range increase in maternal chemical exposures. We detected linear PFOS, PFHxS, octadecanedioic acid, and deoxycholic acid in at least 97% of maternal samples. Correlations ranged between and 0.9. We observed strong correlations between cord and maternal levels of PFHxS, linear PFOS, and branched PFOS (, 0.8, and 0.8, respectively). An interquartile range increase in linear and branched PFOS, tridecanedioic acid, octadecanedioic acid, and deoxycholic acid was associated with increased odds ratio (OR) of GDM [ (95% CI: 0.89, 2.01), 1.24 (95% CI: 0.86, 1.80), 1.26 (95% CI: 0.93, 1.73), 1.24 (95% CI: 0.86, 1.80), and 1.23 (95% CI: 0.87, 1.75), respectively]. Tridecanedioic acid was positively associated with hypertensive disorders of pregnancy [ (95% CI: 0.90, 1.86)]. We identified both exogenous and endogenous chemicals seldom quantified in pregnant study participants that were also related to pregnancy complications and demonstrated the utility of NTA to identify chemical exposures of concern. https://doi.org/10.1289/EHP11546