Fifty shades of inhibition.
Fifty shades of inhibition.
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DOI：
10.1016/j.conb.2016.12.003
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发表时间：
2017-04
影响因子：
5.7
通讯作者：
Maffei A
中科院分区：
文献类型：
--
作者：
Maffei A
抑制回路对大脑功能至关重要。我们对它们的突触组织的理解随着对各种令人印象深刻的神经元群、受体类型和连接模式的识别和分类而广泛发展。然而，关于在神经回路中的作用的概念性讨论仍然围绕着它的主要作用是调节回路兴奋性的想法。在这里，我将集中在最近的研究结果，从皮层电路和认为，抑制电路是中央的传入输入的整合，可以促进复杂的精细规模控制的本地电路。我认为，抑制回路不应该被视为主要神经元活动的刹车，而是各种神经网络功能的主要贡献者。
Inhibitory circuits are essential for brain function. Our understanding of their synaptic organization has advanced extensively with the identification and classification of an impressive variety of neuron groups, receptor types, and patterns of connectivity. However, the conceptual discussion regarding the role of in neural circuits still revolves around the idea that its primary role is to regulate circuit excitability. Here, I will focus on recent findings from cortical circuits and argue that inhibitory circuits are central to the integration of incoming inputs and can promote sophisticated fine-scale control of local circuits. I propose that inhibitory circuits should not be viewed so much as brakes on principal neurons activity, but as primary contributors to a variety of neural network functions.