Women exhibit a greater age-related increase in proximal aortic stiffness than men
Women exhibit a greater age-related increase in proximal aortic stiffness than men
复制标题
DOI：
10.1097/00004872-200112000-00014
复制
发表时间：
2001-12-01
影响因子：
4.9
通讯作者：
Kingwell, BA
中科院分区：
文献类型：
--
作者：
Waddell, TK;Dart, AM;Kingwell, BA
大动脉的力学特性是脉压和心血管结局的主要决定因素。这些属性的性别差异可能是男女之间心血管风险特征变化的基础，与年龄相关。Objective To investigate sexual differences in the age-related stiffening of large arteries.Design Cross-sectional.Methods招募120名健康男性和女性，并按年龄平均分为三分位数：年轻（平均值+/- SD，23 +/- 5岁）、中年（47 +/- 3岁）和老年（62 +/- 7岁）。血脂、平均动脉压和心率在每个三分位数内匹配。结果青年组的体循环动脉顺应性（SAC）无性别差异（均数±标准差，P > 0. 05）。0.61女性的任意依从性单位（ACU）为0.05 +/- 0.05，男性为0.67 +/- 0.04 ACU），但在老年人群中，女性的SAC低于男性（分别为0.27 +/- 0.03 ACU和0.57 +/- 0.04 ACU; P < 0.001）。独立于主动脉几何形状的测量（扩张指数和主动脉阻抗）表明，年轻女性的刚度低于男性（P < 0.05），但在老年人群中则相反（P < 0.01）。肱动脉和颈动脉脉压青年组低于男性（P < 0.01），老年组高于男性（P < 0.05）。卵泡刺激素浓度与所有指标的中心，但不是外周，动脉功能强相关（r值0.39-0.65），而黄体生成素，孕酮和雌二醇的浓度相关性不强。结论在男性和女性匹配的平均压力，年龄相关的大动脉硬化更明显的女性，这是一致的女性激素状态的变化。J Hypertens 19：2205-2212（C）2001 Lippincott威廉姆斯和威尔金斯。
Background Large artery mechanical properties are a major determinant of pulse pressure and cardiovascular outcome. Sex differences in these properties may underlie the variation in cardiovascular risk profile between men and women, in relation to age.Objective To investigate sex differences in the age-related stiffening of large arteries.Design Cross-sectional.Methods One hundred and twenty healthy men and women were recruited and divided equally into tertiles by age: young (mean +/- SD, 23 +/- 5 years), middle-age (47 +/- 3 years) and older (62 +/- 7 years). Lipids, mean arterial pressure and heart rate were matched within each tertile. Carotid tonometry and Doppler velocimetry were used to measure indices of large artery stiffness.Results There was no sex difference in systemic arterial compliance (SAC) in the young group (mean +/- SEM. 0.61 +/- 0.05 arbitrary compliance units (ACU) in women compared with 0.67 +/- 0.04 ACU in men), but in the older population women had lower SAC than men (0.27 +/- 0.03 ACU compared with 0.57 +/- 0.04 ACU respectively; P < 0.001). Measures independent of aortic geometry (distensibility index and aortic impedance) indicated that stiffness was lower in young women than in men (P < 0.05), but the reverse was true in the older population (P < 0.01). This paralleled the brachial and carotid pulse pressures, which were lower in young (P < 0.01) and higher in older women compared with those in men (P < 0.05). Follicle stimulating hormone concentrations correlated strongly (r values 0.39-0.65) with all indices of central, but not peripheral, arterial function, whereas concentrations of luteinizing hormone, progesterone and oestradiol correlated less strongly.Conclusions In men and women matched for mean pressures, the age-related stiffening of large arteries is more pronounced in women, which is consistent with changes in female hormonal status. J Hypertens 19:2205-2212 (C) 2001 Lippincott Williams & Wilkins.