Pre-exposure prophylaxis (PrEP) awareness, attitudes and uptake willingness among young people: gender differences and associated factors in two South African districts.
Pre-exposure prophylaxis (PrEP) awareness, attitudes and uptake willingness among young people: gender differences and associated factors in two South African districts.
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DOI：
10.1080/16549716.2021.1886455
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发表时间：
2021-01-01
影响因子：
2.6
通讯作者：
Nkhwashu N
中科院分区：
文献类型：
--
作者：
Shamu S;Shamu P;Khupakonke S;Farirai T;Chidarikire T;Guloba G;Nkhwashu N
背景：暴露前预防（PrEP）用于预防HIV是安全有效的，可以降低HIV的发病率。然而，需要有更多证据表明PrEP知识、意愿和分布偏好，以便在高危青年中推广。目的：了解青少年对PrEP的认知、意愿和推广偏好。方法：通过多阶段抽样，在低收入社区进行横断面住户调查，选择18- 24岁的年轻人。自我管理的访谈收集了参与者关于PrEP意识，态度，意愿和艾滋病毒风险实践的数据。按性别对数据进行了连续分析。回归模型评估了与地区PrEP意识和意愿相关的因素。结果如下：在接受采访的1917名参与者中，44.6%（男性= 39.4%，女性= 49%，p = 0.001）了解PrEP，49.0%愿意使用PrEP。参与者最喜欢的PrEP分销渠道是公共诊所（51.2%）和医院（23.8%）。更多的男性比女性更喜欢通过学校（11.9%比7.8%; p = 0.002）和非政府组织（8.5%比5.4%; p = 0.008）进行分配。PrEP意愿的最大障碍是PrEP知识不足（10.0%），但更多的男性比女性不喜欢每天服用药丸（4.1%vs2.0%; p值= 0.007）。使用PrEP的性别决定因素是副作用（51%;男性= 47% vs女性= 55%; p = 0.001）和药丸有效性（29.5%;男性= 26.4% vs女性= 32.6%; p = 0.003）。在这两个地区，PrEP知识与女性和媒体使用有关。PrEP意识与多个性伙伴关系，艾滋病毒知识，艾滋病毒自我检测意愿和属于社交俱乐部之间的关联因地区而异。PrEP意愿与每个地区的结核病和PrEP知识呈正相关，但在媒体和职业因素中观察到地区差异。 结论：该研究显示年轻人的PrEP意识水平较低。它还显示了相对增加的意愿，性别化的PrEP意识和分布偏好。促进青年的PrEP意识需要一个多元化的媒体战略。缩略语：艾滋病毒：人体免疫机能丧失病毒;艾滋病：获得性免疫缺陷综合症; aOR：调整优势比; PLWH：艾滋病毒感染者; PrEP：暴露前预防;艾滋病规划署：联合国艾滋病毒和艾滋病联合规划署; uOR：未经调整的比值比; TB：结核病; WHO：世界卫生组织; MSM：男男性行为者
Background: Pre-exposure prophylaxis (PrEP) for HIV prevention is safe and effective in reducing HIV incidence. However, more evidence of PrEP knowledge, willingness and distribution preferences is required for scale-up among young people at-risk. Objective: To understand young people PrEP awareness, willingness and roll-out preferences. Methods: Young people (18–24y) were selected through multi-stage sampling in a cross-sectional household survey in low-income communities. Self-administered interviews collected participants’ data about PrEP awareness, attitudes, willingness and HIV-risk practices. Data were descriptively analysed by gender. Regression models assessed factors associated with PrEP awareness and willingness by district. Results: Of the 1917 participants interviewed 44.6% (men = 39.4% vs women = 49%, p = 0.001) were PrEP aware, 49.0% were willing to use PrEP. Participants most preferred PrEP distribution channels were public clinics (51.2%) and hospitals (23.8%). More men than women preferred distribution through schools (11.9% vs7.8%; p = 0.002) and NGOs (8.5%vs5.4%; p = 0.008). The biggest barrier to PrEP willingness was inadequate PrEP knowledge (10.0%) but more men than women disliked taking pills daily (4.1%vs2.0%; p-value = 0.007). Gendered determinants to use PrEP were side effects (51%; men = 47% vs women = 55%; p = 0.001) and pill effectiveness (29.5%; men = 26.4% vs women = 32.6%; p = 0.003). In both districts PrEP knowledge was associated with being female and media use. The associations between PrEP awareness and having multiple sexual partnerships, HIV knowledge, HIV self-test willingness and belonging to social clubs differed by district. PrEP willingness was positively associated with having TB and PrEP knowledge in each district but district differences were observed in media and occupation factors. Conclusions: The study shows young people’s low levels of PrEP awareness. It also shows relatively increased willingness, gendered PrEP awareness and distribution preferences. Promoting youth’s PrEP awareness requires a multifarious media strategy. Abbreviations: HIV: human immunodeficiency virus; AIDS: Acquired immunodeficiency syndrome; aOR: Adjusted Odds ratio; PLWH: People living with HIV; PrEP: Pre-exposure Prophylaxis; UNAIDS: Joint United Nations Programme on HIV and AIDS; uOR: Unadjusted odds ratio; TB: Tuberculosis; WHO: World health Organisation; MSM: Men who have sex with men
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DOI：
10.1097/qai.0000000000001179
发表时间：
2017-01-01
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
Hosek SG;Rudy B;Landovitz R;Kapogiannis B;Siberry G;Rutledge B;Liu N;Brothers J;Mulligan K;Zimet G;Lally M;Mayer KH;Anderson P;Kiser J;Rooney JF;Wilson CM;Adolescent Trials Network (ATN) for HIVAIDS Interventions
通讯作者：
Adolescent Trials Network (ATN) for HIVAIDS Interventions
影响因子：
12.7
作者：
Khan, Ali S.;Fleischauer, Aaron;Groseclose, Samuel L.
通讯作者：
Groseclose, Samuel L.
影响因子：
4.9
作者：
Grace, Daniel;Jollimore, Jody;Tan, Darrell H. S.
通讯作者：
Tan, Darrell H. S.
影响因子：
3.7
作者：
Goodreau SM;Carnegie NB;Vittinghoff E;Lama JR;Sanchez J;Grinsztejn B;Koblin BA;Mayer KH;Buchbinder SP
通讯作者：
Buchbinder SP
DOI：
10.1016/s2352-3018(15)00206-4
发表时间：
2015-12
期刊：
The lancet. HIV
影响因子：
--
作者：
Deutsch MB;Glidden DV;Sevelius J;Keatley J;McMahan V;Guanira J;Kallas EG;Chariyalertsak S;Grant RM;iPrEx investigators
通讯作者：
iPrEx investigators