Impact of metabolic syndrome on elevated serum alanine aminotransferase levels in the Japanese population.
Impact of metabolic syndrome on elevated serum alanine aminotransferase levels in the Japanese population.
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DOI：
10.1016/j.metabol.2009.03.008
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发表时间：
2009-08
期刊：
影响因子：
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通讯作者：
Takafumi Saito;Y. Nishise;N. Makino;Hiroaki Haga;Rika Ishii;K. Okumoto;Jun-itsu Ito;Hisayoshi Watanabe;Koji Saito;Hiroaki Takeda;H. Togashi;I. Kubota;M. Daimon;T. Kato;S. Kawata
中科院分区：
文献类型：
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作者：
Takafumi Saito;Y. Nishise;N. Makino;Hiroaki Haga;Rika Ishii;K. Okumoto;Jun-itsu Ito;Hisayoshi Watanabe;Koji Saito;Hiroaki Takeda;H. Togashi;I. Kubota;M. Daimon;T. Kato;S. Kawata
血清丙氨酸氨基转移酶（ALT）水平的测量被用作检测肝脏疾病的初始测试，最近的研究也强调了其作为整体健康和生存的衡量标准的潜在价值，作为代谢紊乱风险增加的标志。本研究旨在阐明日本人群ALT水平升高的患病率，并评估与ALT升高相关的因素。受试者为2165名年龄在40至85岁之间的人，他们参加了一项以日本社区为基础的研究，称为Takahata研究。研究血清ALT水平和与ALT升高相关的因素。在2087例B和C型肝炎阴性受试者中，ALT升高大于30 U/L的男性和女性分别为217/957（22.7%）和239/1130（21.2%）。这些ALT临界值对于排除无代谢危险因素或3种代谢危险因素之一（高血压、脂质代谢异常和高血糖）的受试者具有80%以上的特异性。多因素分析显示5个因素与男性ALT升高显著相关（n = 957）：高γ-谷氨酰转肽酶、低脂联素、高低密度脂蛋白胆固醇、高体重指数和高稳态模型评估胰岛素抵抗指数。同样，4个因素与女性ALT升高显著相关（n = 1130）：高γ-谷氨酰转肽酶、低脂联素、高体重指数和高稳态模型评估胰岛素抵抗指数。这些结果表明，日本40岁以上人群中ALT水平升高与代谢综合征相关特征（包括肥胖和胰岛素抵抗）密切相关。
Measurement of the serum alanine aminotransferase (ALT) level is used as an initial test for detection of liver diseases, and recent studies have also highlighted its potential value as a measure of overall health and survival as a marker of an increased risk of metabolic disorder. This study was designed to clarify the prevalence of elevated ALT levels in the Japanese population and to assess factors associated with ALT elevation. The subjects were 2165 individuals aged 40 to 85 years who participated in a Japanese community-based study referred to as the Takahata Study. Serum ALT levels and factors associated with ALT elevation were investigated. Among 2087 subjects who were negative for hepatitis B and C, the rates of elevated ALT greater than 30 U/L in men and greater than 25 U/L in women were 217 (22.7%) of 957 and 239 (21.2%) of 1130, respectively. These ALT cutoff levels had a specificity of more than 80% for exclusion of subjects with none or 1 of 3 metabolic risk factors: hypertension, lipid metabolism abnormality, and hyperglycemia. Multivariate analysis revealed 5 factors with a significant association with ALT elevation in men (n = 957): high γ-glutamyltranspeptidase, low adiponectin, high low-density lipoprotein cholesterol, high body mass index, and high homeostasis model assessment insulin resistance index. Similarly, 4 factors were significantly associated with ALT elevation in women (n = 1130): high γ-glutamyltranspeptidase, low adiponectin, high body mass index, and high homeostasis model assessment insulin resistance index. These results suggest that elevated ALT levels in the Japanese population older than 40 years have a strong association with metabolic syndrome–related features including obesity and insulin resistance.