PRIMARY STRUCTURE OF THE HUMAN MET-ENKEPHALIN AND LEU-ENKEPHALIN PRECURSOR AND ITS MESSENGER-RNA
PRIMARY STRUCTURE OF THE HUMAN MET-ENKEPHALIN AND LEU-ENKEPHALIN PRECURSOR AND ITS MESSENGER-RNA
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DOI：
10.1038/295663a0
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发表时间：
1982-01-01
期刊：
影响因子：
64.8
通讯作者：
HERBERT, E
中科院分区：
文献类型：
--
作者：
COMB, M;SEEBURG, PH;HERBERT, E
报告了来自人嗜铬细胞瘤的脑啡肽前体 mRNA 的完整 cDNA 拷贝的核苷酸序列。相应的氨基酸序列显示该前体有267个氨基酸长并且包含6个散布的Met-脑啡肽序列和1个Leu-脑啡肽序列。七个脑啡肽中的五个两侧都有成对的碱性氨基酸残基。前体不包含阿片肽、强啡肽、α-新内啡肽或β-内啡肽的序列。
The nucleotide sequence of a complete cDNA copy of enkephalin precursor mRNA from human phaeochromocytoma is reported. The corresponding amino acid sequence shows that the precursor is 267 amino acids long and contains six interspersed Met-enkephalin sequences and one Leu-enkephalin sequence. Five of the seven enkephalins are flanked on both sides by pairs of basic amino acid residues. The precursor does not contain the sequences of the opioid peptides, dynorphin, α-neo-endorphin or β-endorphin.