Antidepressant-like activity of a Kampo (Japanese herbal) medicine, Koso-san (Xiang-Su-San), and its mode of action via the hypothalamic-pituitary-adrenal axis
Antidepressant-like activity of a Kampo (Japanese herbal) medicine, Koso-san (Xiang-Su-San), and its mode of action via the hypothalamic-pituitary-adrenal axis
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DOI：
10.1016/j.phymed.2006.01.002
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发表时间：
2006-11-01
期刊：
影响因子：
7.9
通讯作者：
Yamada, H.
中科院分区：
文献类型：
--
作者：
Ito, N.;Nagai, T.;Yamada, H.
香苏散（中国），汉方（日本草药）药物，在东亚临床上用于治疗与普通感冒初期相关的抑郁样症状、食物摄入引起的过敏性荨麻疹、肠易激综合征、慢性疲劳综合征、失眠和自主神经失调。然而，抗抑郁药的活性从来没有被科学地评估。在这项研究中，ddY小鼠受到强迫游泳和慢性轻度应激的组合被称为抑郁样模型小鼠。抑郁样状态的程度通过使用强迫游泳试验（FST）的动物不动的持续时间来测量。经口给药的EST-SAN（1.0 g/kg/体重/天，9天）显著缩短了抑郁样模型小鼠在FST中的不动持续时间;然而，自发活动不受影响。下丘脑-垂体-肾上腺（HPA）轴的过度活跃在抑郁症的病理生理中起着重要作用。抑郁样模型小鼠下丘脑促肾上腺皮质激素释放激素mRNA和垂体阿黑皮素原mRNA表达水平显著升高，下丘脑室旁核糖皮质激素受体蛋白表达下调。本研究结果提示，丹参通过抑制抑郁样模型小鼠HPA轴的过度活动，发挥抗抑郁样作用。(c)2006年Elsevier GmbH。All rights reserved.
Koso-san (Xiang-Su-San in Chinese), a Kampo (Japanese herbal) medicine, is used clinically in East Asia for the treatment of depression-like symptoms associated with the initial stage of the common cold, allergic urticaria due to food ingestion, irritable bowel syndrome, chronic fatigue syndrome, insomnia, and autonomic imbalance. However, the antidepressant-like activity of Koso-san has never been evaluated scientifically. In this study, ddY mice subjected to a combination of forced swimming and chronic mild stresses were termed depression-like model mice. The degree of the depression-like state was measured by the animal's duration of immobility using the forced swimming test (FST). Oral administration of Koso-san (1.0 g/kg/body wt./day, 9 days) significantly shortened the duration of immobility of the depression-like, model mice in the FST; however, locomotor activity was not affected. Hyperactivity of the hypothalamic-pitultary-adrenal (HPA) axis plays an important role in the pathophysiology of depression. Levels of corticotropin-releasing hormone mRNA expression in the hypothalamus and proopiomelanocortin mRNA expression in the pituitary were significantly increased, and glucocorticoid receptor protein expression in the hypothalamus paraventricular nucleus was downregulated in the depression-like model mice. However, Koso-san ameliorated these alterations to the normal conditions.The results of this study suggest that Koso-san shows the antidepressant-like effect through suppressing the hyperactivity of the HPA axis in depression-like model mice. (c) 2006 Elsevier GmbH. All rights reserved.