Possible association of tumor necrosis factor receptor 2 gene polymorphism with severe hypertension using the extreme discordant phenotype design
Possible association of tumor necrosis factor receptor 2 gene polymorphism with severe hypertension using the extreme discordant phenotype design
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DOI：
10.1038/hr.2009.91
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发表时间：
2009-09-01
影响因子：
5.4
通讯作者：
Saruta, Takao
中科院分区：
文献类型：
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作者：
Eguchi, Takashi;Maruyama, Tatsuya;Saruta, Takao
肿瘤坏死因子(TNF)- α通路在调节胰岛素抵抗中起关键作用。TNF受体2 （TNFR2）是原发性高血压患者胰岛素抵抗的新候选基因。我们研究了胰岛素抵抗和TNF通路增强与严重高血压的关系，以及TNFR2基因微卫星多态性与严重高血压的关系。本研究连续纳入60岁前发病且有高血压遗传易感性的男性重度原发性高血压患者（HT） （N=92）。50岁以上的正常血压男性（NT）从年度健康检查计划的参与者中随机登记（N=78）。符合收缩压/舒张压（SBP/DBP）水平（>= 180和/或110 mm Hg）严格标准的患者被选为HT和NT
The tumor necrosis factor (TNF)-alpha pathway has a key role in regulating insulin resistance. TNF receptor 2 (TNFR2) is an emerging candidate gene for insulin resistance in essential hypertension. We examined the association of insulin resistance and enhanced TNF pathway with severe hypertension and the association of a microsatellite polymorphism of the TNFR2 gene with severe hypertension. Male severe essential hypertensive patients (HT) with the onset before 60 years of age and with genetic predispositions to hypertension were consecutively enrolled at our outpatient department (N=92). Normotensive men (NT) over 50 years of age were randomly registered from the participants in the annual health check program (N=78). Patients were selected as HT and NT who met stringent criteria for systolic/diastolic blood pressure (SBP/DBP) levels >= 180 and/or 110 mm Hg and